Title:
GENE AMPLIFICATION IN CANCER
Document Type and Number:
WIPO Patent Application WO2003079982
Kind Code:
A3
Abstract:
There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the CTSZ and CD24 genes, which are amplified colon cancer and/or ovarian cancer and/or breast cancer genes. The CTSZ and CD24 genes, their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or vaccine; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.
Inventors:
LI JING (US)
POWERS SCOTT (US)
YANG JIANXIN (US)
POWERS SCOTT (US)
YANG JIANXIN (US)
Application Number:
PCT/US2003/008305
Publication Date:
November 11, 2004
Filing Date:
March 18, 2003
Export Citation:
Assignee:
TULARIK INC (US)
LI JING (US)
POWERS SCOTT (US)
YANG JIANXIN (US)
LI JING (US)
POWERS SCOTT (US)
YANG JIANXIN (US)
International Classes:
A61K48/00; C07H21/02; C07H21/04; C12M1/34; C12P19/34; C12Q1/68; G01N33/574; (IPC1-7): G01N33/00
Foreign References:
| US20030159168A1 | 2003-08-21 | |||
| US20030224511A1 | 2003-12-04 |
Other References:
SANTAMARIA I. ET AL: "Cathepsin Z, a Novel Human Cysteine Proteinase with a Short Propeptide Domain and a Unique Chromosomal Location", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 27, 3 July 1998 (1998-07-03), pages 16815 - 16823, XP002981019
MAHLAMAKI E.H. ET AL: "Frequent Amplification of 8q24, 11q, 17q, and 20q-Specific Genes in Pancreatic Cancer", GENES, CHROMOSOMES & CANCER, vol. 35, no. 4, 2002, pages 353 - 358, XP002981204
SANTAMARIA I. ET AL: "Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas", CANCER RESEARCH, vol. 58, 15 April 1998 (1998-04-15), pages 1624 - 1630, XP002079573
MAHLAMAKI E.H. ET AL: "Frequent Amplification of 8q24, 11q, 17q, and 20q-Specific Genes in Pancreatic Cancer", GENES, CHROMOSOMES & CANCER, vol. 35, no. 4, 2002, pages 353 - 358, XP002981204
SANTAMARIA I. ET AL: "Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas", CANCER RESEARCH, vol. 58, 15 April 1998 (1998-04-15), pages 1624 - 1630, XP002079573
Download PDF:
Previous Patent: BIOADHESIVE DRUG DELIVERY SYSTEM
Next Patent: METHODS OF PREPARING SUBSTITUTED TETRACYCLINES WITH TRANSITION METAL-BASED CHEMISTRIES
Next Patent: METHODS OF PREPARING SUBSTITUTED TETRACYCLINES WITH TRANSITION METAL-BASED CHEMISTRIES