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Title:
GENE CASSETTE FOR FINE CONTROL OF COMPOSITION RATIO OF 4-HYDROXYBUTANOIC ACID IN COPOLYMER AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/233703
Kind Code:
A1
Abstract:
Provided are a gene cassette for fine control of a composition ratio of 4-hydroxybutanoic acid in a polyhydroxyalkanoate (PHA) copolymer, a bacterial recombinant strain comprising the gene cassette, and a method for preparing the polyhydroxyalkanoate (PHA) copolymer. The gene cassette comprises a promoter and a 4-hydroxybutyrate coenzyme A transferase gene or a gene having functions of 4-hydroxybutyrate coenzyme A transferase.

Inventors:
LI, Teng (Room218, Building 1# PKUCare Industrial Park, Zhongguancun,Life Science Park, Changping District, Beijing 6, 102206, CN)
YE, Jianwen (Room218, Building 1# PKUCare Industrial Park, Zhongguancun,Life Science Park, Changping District, Beijing 6, 102206, CN)
YIN, Jin (Room218, Building 1# PKUCare Industrial Park, Zhongguancun,Life Science Park, Changping District, Beijing 6, 102206, CN)
CHEN, Xiangbin (Room218, Building 1# PKUCare Industrial Park, Zhongguancun,Life Science Park, Changping District, Beijing 6, 102206, CN)
Application Number:
CN2018/092467
Publication Date:
December 27, 2018
Filing Date:
June 22, 2018
Export Citation:
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Assignee:
BLUEPHA CO., LTD. (Room218, Building 1# PKUCare Industrial Park, Zhongguancun,Life Science Park, Changping District, Beijing 6, 102206, CN)
International Classes:
C12N15/63
Foreign References:
CN102676567A2012-09-19
CN101906394A2010-12-08
CN101008011A2007-08-01
US20100093043A12010-04-15
Other References:
ZHAO HAN, ZHANG HAOQIAN M., CHEN XIANGBIN, LI TENG, WU QIONG, OUYANG QI, CHEN GUO-QIANG: "Novel T7-like expression systems used for Halomonas", METABOLIC ENGINEERING, vol. 39, 24 November 2016 (2016-11-24), pages 128 - 140, XP029880934, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2016.11.007
ZHENG-JUN LI, ZHEN-YU SHI, JIA JIAN, YING-YING GUO, ... GUO-QIANG CHEN: "Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from unrelated carbon sources by metabolically engineered Escherichia coli", METABOLIC ENGINEERING, vol. 12, no. 4, 18 March 2010 (2010-03-18), pages 352 - 359, XP027079422, ISSN: 1096-7176, DOI: 10.1016/j.ymben.2010.03.003
XIANGBIN CHEN, JIN YIN, JIANWEN YE, HAOQIAN ZHANG, GUO-QIANG CHEN: "Engineering Halomonas bluephagenesis TD01 for non-sterile production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate)", BIORESOURCE TECHNOLOGY, vol. 244, no. part 1, 27 July 2017 (2017-07-27), pages 534 - 541, XP085199093, ISSN: 0960-8524, DOI: 10.1016/j.biortech.2017.07.149
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (704 Block B, Xinyu Commercial Building90 Guangqumen Inner Stree, Dongcheng District Beijing 2, 100062, CN)
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