GENE EDITED LIVESTOCK ANIMALS HAVING CORONAVIRUS RESISTANCE

Title:

GENE EDITED LIVESTOCK ANIMALS HAVING CORONAVIRUS RESISTANCE

Document Type and Number:

WIPO Patent Application WO/2024/013514

Kind Code:

A3

Abstract:

Livestock animals and progeny thereof comprising at least one edited chromosomal sequence that reduces expression or activity of an ANPEP protein are provided. Livestock animal cells that contain such edited chromosomal sequences are also provided. The livestock animals, progeny, and cells have increased resistance to coronavirus. Methods for producing coronavirus resistant livestock animals are also provided.

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Inventors:

BURGER BRIAN (US)
BEATON BENJAMIN (US)

Application Number:

PCT/GB2023/051854

Publication Date:

February 22, 2024

Filing Date:

July 14, 2023

Export Citation:

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Assignee:

PIG IMPROVEMENT CO UK LTD (GB)

International Classes:

A01K67/027; C12N9/22; C12N9/64; C12N15/113

Domestic Patent References:

WO2019210175A1	2019-10-31
WO2022063160A1	2022-03-31

Foreign References:

KR101961667B1	2019-03-25
CN113957069A	2022-01-21
CN107893088A	2018-04-10

Other References:

WHITWORTH KRISTIN M ET AL: "Resistance to coronavirus infection in amino peptidase N-deficient pigs", TRANSGENIC RESEARCH, SPRINGER NETHERLANDS, NL, vol. 28, no. 1, 12 October 2018 (2018-10-12), pages 21 - 32, XP036695341, ISSN: 0962-8819, [retrieved on 20181012], DOI: 10.1007/S11248-018-0100-3
JIANWEN CHEN ET AL: "Production of porcine aminopeptidase N (pAPN) site-specific edited pigs", ANIMAL SCIENCE JOURNAL - NIHON CHIKUSAN GAKKAIHO, JAPANESE SOCIETY OF ZOOTECHNICAL SCIENCE., TOKYO, JP, vol. 90, no. 3, 8 January 2019 (2019-01-08), pages 366 - 371, XP072022335, ISSN: 1344-3941, DOI: 10.1111/ASJ.13163
DATABASE Geneseq [online] 16 May 2019 (2019-05-16), "Pig APN gene forward PCR primer.", XP002810291, retrieved from EBI accession no. GSN:BGE35689 Database accession no. BGE35689

Attorney, Agent or Firm:

J A KEMP LLP (GB)

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