Title:
GENE EXPRESSION MARKERS FOR RESPONSE TO EGFR INHIBITOR DRUGS
Document Type and Number:
WIPO Patent Application WO2004071572
Kind Code:
A3
Abstract:
The present invention concerns prognostic markers associated with cancer. In particular, the invention concerns prognostic methods based on the molecular charaterization of gene expression in paraffin-embedded, fixed samples of cancer tissue, which allow a physician to predict whether a patient is likely to respond well to treatment with an EGFR inhibitor.
Inventors:
AGUS DAVID (US)
SHAK STEVE (US)
CRONIN MAUREEN T (US)
BAKER JOFFRE B (US)
SHAK STEVE (US)
CRONIN MAUREEN T (US)
BAKER JOFFRE B (US)
Application Number:
PCT/US2004/003596
Publication Date:
January 13, 2005
Filing Date:
February 05, 2004
Export Citation:
Assignee:
GENOMIC HEALTH INC (US)
CEDARS SINAI MEDICAL CENTER (US)
AGUS DAVID (US)
SHAK STEVE (US)
CRONIN MAUREEN T (US)
BAKER JOFFRE B (US)
CEDARS SINAI MEDICAL CENTER (US)
AGUS DAVID (US)
SHAK STEVE (US)
CRONIN MAUREEN T (US)
BAKER JOFFRE B (US)
International Classes:
C12Q1/68; (IPC1-7): C12Q1/68
Domestic Patent References:
| WO2002047007A2 | 2002-06-13 | |||
| WO2002024867A2 | 2002-03-28 |
Foreign References:
| US20020192652A1 | 2002-12-19 |
Other References:
HUMPHREYS R C ET AL: "Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis.", CELL GROWTH & DIFFERENTIATION : THE MOLECULAR BIOLOGY JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. OCT 1999, vol. 10, no. 10, October 1999 (1999-10-01), pages 685 - 694, XP002286318, ISSN: 1044-9523
VEER VAN 'T L J ET AL: "Gene expression profiling predicts clinical outcome of breast cancer", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 415, no. 6871, 31 January 2002 (2002-01-31), pages 530 - 536, XP002259781, ISSN: 0028-0836
HINZ MICHAEL ET AL: "Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.", THE JOURNAL OF EXPERIMENTAL MEDICINE. 2 SEP 2002, vol. 196, no. 5, 2 September 2002 (2002-09-02), pages 605 - 617, XP002286321, ISSN: 0022-1007
CRISTILLO ANTHONY D ET AL: "Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 8 FEB 2002, vol. 277, no. 6, 8 February 2002 (2002-02-08), pages 4465 - 4476, XP002286319, ISSN: 0021-9258
ARTEAGA C L: "THE EPIDERMAL GROWTH FACTOR RECEPTOR: FROM MUTANT ONCOGENE IN NONHUMAN CANCERS TO THERAPEUTIC TARGET IN HUMAN NEOPLASIA", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 19, no. 18, SUPPL, 15 September 2001 (2001-09-15), pages 32S - 40S, XP008031982, ISSN: 0732-183X
GODFREY T E ET AL: "Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5' nuclease quantitative reverse transcription-polymerase chain reaction.", THE JOURNAL OF MOLECULAR DIAGNOSTICS : JMD. MAY 2000, vol. 2, no. 2, May 2000 (2000-05-01), pages 84 - 91, XP002286320, ISSN: 1525-1578
VEER VAN 'T L J ET AL: "Gene expression profiling predicts clinical outcome of breast cancer", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 415, no. 6871, 31 January 2002 (2002-01-31), pages 530 - 536, XP002259781, ISSN: 0028-0836
HINZ MICHAEL ET AL: "Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity.", THE JOURNAL OF EXPERIMENTAL MEDICINE. 2 SEP 2002, vol. 196, no. 5, 2 September 2002 (2002-09-02), pages 605 - 617, XP002286321, ISSN: 0022-1007
CRISTILLO ANTHONY D ET AL: "Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 8 FEB 2002, vol. 277, no. 6, 8 February 2002 (2002-02-08), pages 4465 - 4476, XP002286319, ISSN: 0021-9258
ARTEAGA C L: "THE EPIDERMAL GROWTH FACTOR RECEPTOR: FROM MUTANT ONCOGENE IN NONHUMAN CANCERS TO THERAPEUTIC TARGET IN HUMAN NEOPLASIA", JOURNAL OF CLINICAL ONCOLOGY, GRUNE AND STRATTON, NEW YORK, NY, US, vol. 19, no. 18, SUPPL, 15 September 2001 (2001-09-15), pages 32S - 40S, XP008031982, ISSN: 0732-183X
GODFREY T E ET AL: "Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5' nuclease quantitative reverse transcription-polymerase chain reaction.", THE JOURNAL OF MOLECULAR DIAGNOSTICS : JMD. MAY 2000, vol. 2, no. 2, May 2000 (2000-05-01), pages 84 - 91, XP002286320, ISSN: 1525-1578
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