Title:
GENE INTERFERENCE VECTOR- AND IRON NANOPARTICLE-BASED COMPOSITION FOR KILLING CANCER CELLS, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/179792
Kind Code:
A1
Abstract:
Disclosed in the present invention are a gene interference vector- and iron nanoparticle-based composition for killing cancer cells, and the use thereof. The composition comprises a gene interference vector and iron nanoparticles, wherein the gene interference vector is a CRISPR/Cas13a expression vector or microRNA expression vector controlled by a cancer cell specific promoter DMP, with the Cas13a-gRNA or microRNA expressed by the vector being able to inhibit, in a targeted manner, intracellular iron metabolism and the expression of reactive oxygen related genes, and the iron nanoparticles can be degraded after entering cells to produce iron ions and to increase the reactive oxygen level. The composition comprising the gene interference vector and the iron nanoparticles of the present invention can be used for preparing a new reagent for treating cancers.
Inventors:
WANG JINKE (CN)
GAO JINLIANG (CN)
LUO TAO (CN)
GAO JINLIANG (CN)
LUO TAO (CN)
Application Number:
PCT/CN2021/072025
Publication Date:
September 16, 2021
Filing Date:
January 15, 2021
Export Citation:
Assignee:
UNIV SOUTHEAST (CN)
International Classes:
C12N15/00; A61P35/00; C07F15/02
Foreign References:
| US20170239370A1 | 2017-08-24 | |||
| CN102631687A | 2012-08-15 | |||
| CN107557393A | 2018-01-09 | |||
| CN107365785A | 2017-11-21 | |||
| CN111249477A | 2020-06-09 |
Other References:
ZHOU LIANGFU, ZHAO BIN, ZHANG LIXIU, WANG SHENGHANG, DONG DANDAN, LV HUANHUAN, SHANG PENG: "Alterations in Cellular Iron Metabolism Provide More", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE, vol. 19, no. 5, 1545, 22 May 2018 (2018-05-22), pages 1 - 21, XP055846524, DOI: 10.3390/ijms19051545
Attorney, Agent or Firm:
NANJING SUGAO PATENT AND TRADEMARK FIRM ( ORDINARY PARTNERSHIP ) (CN)
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