Title:
GENE-MODIFIED NON-HUMAN ANIMAL EXPRESSING HUMAN GPC3 POLYPEPTIDE
Document Type and Number:
WIPO Patent Application WO/2018/038046
Kind Code:
A1
Abstract:
Provided are: a gene-modified non-human animal that lacks endogenous GPC3 polypeptide expression and expresses human GPC3 polypeptide at a physiologically reasonable level; a method for producing the non-human animal; and a method for evaluating a test substance with the use of the non-human animal. Also provided is a method for evaluating the safety, therapeutic effect on a disease, drug kinetics, biological distribution, etc., of a test substance with the use of the non-human animal as a model.
Inventors:
JISHAGE KOICHI (JP)
HINO HIROSHI (JP)
ISHIGURO TAKAHIRO (JP)
KINOSHITA YASUKO (JP)
HINO HIROSHI (JP)
ISHIGURO TAKAHIRO (JP)
KINOSHITA YASUKO (JP)
Application Number:
PCT/JP2017/029766
Publication Date:
March 01, 2018
Filing Date:
August 21, 2017
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/09; A01K67/027; C07K16/28; C12N5/10; C12P21/08; G01N33/15; G01N33/50
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See also references of EP 3502250A4
PROC. NATL. ACAD. SCI. U.S.A, vol. 108, no. 6, 8 February 2011 (2011-02-08), pages 2390 - 2395
INT. J. BIOCHEM. CELL. BIOL., vol. 40, no. 11, 2008, pages 2384 - 2396
J. CELL. BIOL., vol. 181, no. 2, 21 April 2008 (2008-04-21), pages 189 - 194
RNA. BIOL., vol. 5, no. 4, October 2008 (2008-10-01), pages 201 - 207
NATL. ACAD. SCI. U.S.A., vol. 85, pages 836 - 840
KANATSU-SHINOHARA, M. ET AL., BIOL. REPROD., vol. 79, 2008, pages 1121 - 1128
CUI, X. ET AL., NAT. BIOTECHNOL., vol. 29, 2011, pages 64 - 67
LI, T. ET AL., NUCLEIC ACIDS RES., vol. 39, 2011, pages 6315 - 6325
YANG, H. ET AL., CELL.IN PRESS, 2013
NIU, Y. ET AL., J. GENET. GENOMICS, vol. 35, 2008, pages 701 - 714
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, vol. 94, no. 2, April 2013 (2013-04-01), pages 93 - 103
IGAWA ET AL., NAT. BIOTECHNOL., vol. 28, 2010, pages 1203 - 1207
MORRISON ET AL., PROC. NATL. ACAD. SCI. USA, vol. 81, 1984, pages 6851 - 6855
ALMAGRO; FRANSSON, FRONT. BIOSCI., vol. 13, 2008, pages 1619 - 1633
VAN DIJK AND VAN DE WINKEL, CURR. OPIN. PHARMACOL., vol. 5, 2001, pages 368 - 74
LONBERG, CURR. OPIN. IMMUNOL., vol. 20, 2008, pages 450 - 459
HOOGENBOOM ET AL., METHODS IN MOLECULAR BIOLOGY, vol. 178, pages 1 - 37
MILSTEIN; CUELLO, NATURE, vol. 305, 1983, pages 537
TRAUNECKER ET AL., EMBO J., vol. 10, 1991, pages 3655
BRENNAN, SCIENCE, vol. 229, 1985, pages 81
KOSTELNY, J. IMMUNOL., vol. 148, no. 5, 1992, pages 1547 - 1553
HOLLIGER, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
GRUBER, J. IMMUNOL., vol. 152, 1994, pages 5368
TUTT, J. IMMUNOL., vol. 147, 1991, pages 60
WANG ET AL., PNAS, vol. 91, 1994, pages 9402 - 9406
PROTEIN SCIENCE, vol. 4, 1995, pages 2411 - 2423
BLOOD, vol. 106, 2005, pages 3127 - 3133
See also references of EP 3502250A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
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