Title:
GENE NETWORK CONSTRUCTION APPARATUS AND METHOD
Document Type and Number:
WIPO Patent Application WO/2019/117400
Kind Code:
A1
Abstract:
The present invention proposes a gene network construction apparatus and method for constructing an Alzheimer's disease (AD)-specific gene network by selecting gene pairs from among gene samples on the basis of mutual information amounts of genes and extracting sub-networks associated with AD from the gene pairs. The apparatus according to the present invention comprises: a gene pair selection unit for selecting first gene pairs associated with AD from among predetermined gene samples on the basis of a first mutual information amount of genes associated with people without having AD and a second mutual information amount of genes associated with people having AD; a gene pair integration unit for integrating the first gene pairs by using a node property on the basis of information on a pathway of each gene pair; a sub-network extraction unit for extracting sub-networks associated with AD on the basis of a seed-based search method when the first gene pairs are integrated; and a gene network construction unit for constructing the AD-specific gene network on the basis of the sub-networks associated with AD.
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Inventors:
PARK SANG HYUN (KR)
PARK CHI HYUN (KR)
PARK CHI HYUN (KR)
Application Number:
PCT/KR2018/002915
Publication Date:
June 20, 2019
Filing Date:
March 13, 2018
Export Citation:
Assignee:
UNIV INDUSTRY FOUNDATION UIF YONSEI UNIV (KR)
International Classes:
G16B5/00; G16B40/00; G16B50/00
Foreign References:
| US20050241010A1 | 2005-10-27 | |||
| US20070072226A1 | 2007-03-29 |
Other References:
KAWALIA, S. B. ET AL.: "Analytical strategy to prioritize Alzheimer's disease candidate genes in gene regulatory networks using public expression data", JOURNAL OF ALZHEIMER'S DISEASE, vol. 59, no. 4, 14 August 2017 (2017-08-14), pages 1237 - 1254, XP055617238
LIU, Y.: "Integrative analysis of common neurodegenerative diseases using gene association, interaction networks and mRNA expression data", AMIA JOINT SUMMITS ON TRANSLATIONAL SCIENCE PROCEEDINGS, vol. 2012, 2012, pages 62 - 71, XP055617241
TIAN, Z.: "Constructing an integrated gene similarity network for the identification of disease genes", JOURNAL OF BIOMEDICAL SEMANTICS, vol. 8, no. Suppl.1, 16 December 2016 (2016-12-16) - 20 September 2017 (2017-09-20), pages 27 - 41, XP055617247
PARK, C.: "Systematic identification of differential gene network to elucidate Alzheimer' s disease", EXPERT SYSTEMS WITH APPLICATIONS, 17 May 2017 (2017-05-17), pages 249 - 260, XP085066044, doi:10.1016/j.eswa.2017.05.042
LIU, Y.: "Integrative analysis of common neurodegenerative diseases using gene association, interaction networks and mRNA expression data", AMIA JOINT SUMMITS ON TRANSLATIONAL SCIENCE PROCEEDINGS, vol. 2012, 2012, pages 62 - 71, XP055617241
TIAN, Z.: "Constructing an integrated gene similarity network for the identification of disease genes", JOURNAL OF BIOMEDICAL SEMANTICS, vol. 8, no. Suppl.1, 16 December 2016 (2016-12-16) - 20 September 2017 (2017-09-20), pages 27 - 41, XP055617247
PARK, C.: "Systematic identification of differential gene network to elucidate Alzheimer' s disease", EXPERT SYSTEMS WITH APPLICATIONS, 17 May 2017 (2017-05-17), pages 249 - 260, XP085066044, doi:10.1016/j.eswa.2017.05.042
Attorney, Agent or Firm:
WOOIN PATENT & LAW FIRM (KR)
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