GENE THERAPY DRUG FOR CANCER, MEDICINAL COMPOSITION, AND THERAPEUTIC METHOD

Title:

GENE THERAPY DRUG FOR CANCER, MEDICINAL COMPOSITION, AND THERAPEUTIC METHOD

Document Type and Number:

WIPO Patent Application WO/1996/007433

Kind Code:

A1

Abstract:

A gene therapy drug for cancer containing effector cells having cytokine genes introduced thereinto and tumor vaccines comprising tumor cells having cytokine genes introduced thereinto; a method of gene therapy for cancers by administering a pharmaceutical preparation containing the effector cells and a pharmaceutical preparation containing the tumor vaccines to a patient with cancer; and a medicinal composition containing a combination of the effector cells and the tumor vaccines. The drug, composition and method produce a high antitumor effect, have the effect of inhibiting cancer metastasis, and are useful for treating micrometastatic cancer.

Inventors:

HAMADA HIROFUMI (JP)
SUGANO HARUO (JP)

Application Number:

PCT/JP1995/001785

Publication Date:

March 14, 1996

Filing Date:

September 08, 1995

Export Citation:

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Assignee:

JAPAN FOUND CANCER (JP)
HAMADA HIROFUMI (JP)
SUGANO HARUO (JP)

International Classes:

C12N5/10; A61K38/19; A61K39/00; A61K48/00; A61P35/00; (IPC1-7): A61K48/00

Domestic Patent References:

WO1993007906A1	1993-04-29
WO1993019191A1	1993-09-30
WO1993021959A1	1993-11-11

Foreign References:

JPH06157333A

1994-06-03

Other References:

PROC. NATL. ACAD. SCI. U.S.A., Vol. 90, (1993), GLENN DRANOFF et al., pages 3539-3543.
CELL, Vol. 60, (1990), ERIC R. FEARON et al., pages 397-403.
THE JOURNAL OF IMMUNOLOGY, Vol. 150, (1993), PATRICK HWU et al., pages 4104-4115.
STRIDES OF MEDICINE, Vol. 167, No. 5, (1993), MINORU TAKAHASHI et al., pages 270-276.

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