GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS

Title:

GENE THERAPY FOR IMMUNO-ONCOLOGY APPLICATIONS

Document Type and Number:

WIPO Patent Application WO/2022/006332

Kind Code:

A3

Abstract:

The invention provides compositions and methods for treatment of glioblastoma and other conditions. In particular, the invention provides a recombinant adeno-associated virus (AAV) vector comprising a transgene encoding one or more interferon polypeptides and a CAG promoter which directs the expression of the transgene. The compositions are particularly suitable for intratumoral administration in gene therapy applications.

Inventors:

PAULK NICOLE K (US)
DERISI JOSEPH L (US)
RALEIGH DAVID R (US)

Application Number:

PCT/US2021/039983

Publication Date:

February 03, 2022

Filing Date:

June 30, 2021

Export Citation:

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Assignee:

CHAN ZUCKERBERG BIOHUB INC (US)
UNIV CALIFORNIA (US)

International Classes:

A61K35/15; A61K35/28; A61K38/21

Foreign References:

US20130195800A1	2013-08-01
US20170283810A1	2017-10-05

Attorney, Agent or Firm:

LOCKYER, Jean M. et al. (US)

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