Title:
GENE THERAPY USING REPLICATION COMPETENT TARGETED GENE THERAPY USING REPLICATION COMPETENT TARGETED ADENOVIRAL VECTORS ADENOVIRAL VECTORS
Document Type and Number:
WIPO Patent Application WO1996034969
Kind Code:
A3
Abstract:
This invention provides a method of treating cancer by administering a replication competent adenoviral vector comprising a therapeutic gene and a disease specific gene regulatory region operationally linked to at least one replication gene. The replication competent targeted adenoviral vector preferentially replicates in the tumor cells following activation of the tumor specific gene regulatory region thereby amplifying the effect of the therapeutic gene carried by the replication competent adenoviral vector. This invention enables for the first time the targeting of a therapeutic gene for treating cancer using small amounts of viral vectors which selectively replicate to deliver therapeutic dosages of the therapeutic gene.
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Inventors:
GREGORY RICHARD J
HUANG WHEI-MEI
HUANG WHEI-MEI
Application Number:
PCT/US1996/006199
Publication Date:
February 13, 1997
Filing Date:
May 02, 1996
Export Citation:
Assignee:
CANJI INC (US)
International Classes:
A61K35/76; A61K38/45; C12N15/09; A61K48/00; A61P35/00; A61P37/00; A61P43/00; C12N15/861; (IPC1-7): C12N15/86; A61K48/00
Domestic Patent References:
| WO1996017053A1 | 1996-06-06 | |||
| WO1994018992A1 | 1994-09-01 | |||
| WO1995011984A2 | 1995-05-04 |
Other References:
Y.-HAJ-AHMAD AND F.L. GRAHAM: "Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene", J. VIROLOGY, vol. 57, no. 1, January 1986 (1986-01-01), AM.SOC.MICROBIOL.,WASHINGTON,US, pages 267 - 274, XP002014457
J.E. MORIN ET AL.: "Recombinant adenovirus induces antibody response to hepatitis B virus surface antigen in hamster", PROC. NATL.ACAD SCI., vol. 84, July 1987 (1987-07-01), NATL. ACAD SCI.,WASHINGTON,DC,US;, pages 4626 - 4630, XP002014458
L. PREVEC ET AL.: "A recombinant human adenovirus vaccine against rabies", J. INFECTIOUS DISEASES, vol. 161, 1990, UNIVERSITY CHICAGO, US, pages 27 - 30, XP002014459
S.K. MITTAL ET AL.: "Development of a bobine adenovirus type 3-based expression vector", J. GENERAL VIROLOGY, vol. 76, no. 1, January 1995 (1995-01-01), READING, BERKS, GB, pages 93 - 102, XP002014460
J.E. MORIN ET AL.: "Recombinant adenovirus induces antibody response to hepatitis B virus surface antigen in hamster", PROC. NATL.ACAD SCI., vol. 84, July 1987 (1987-07-01), NATL. ACAD SCI.,WASHINGTON,DC,US;, pages 4626 - 4630, XP002014458
L. PREVEC ET AL.: "A recombinant human adenovirus vaccine against rabies", J. INFECTIOUS DISEASES, vol. 161, 1990, UNIVERSITY CHICAGO, US, pages 27 - 30, XP002014459
S.K. MITTAL ET AL.: "Development of a bobine adenovirus type 3-based expression vector", J. GENERAL VIROLOGY, vol. 76, no. 1, January 1995 (1995-01-01), READING, BERKS, GB, pages 93 - 102, XP002014460
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