Title:
GENERATION OF DIVERSITY IN COMBINATORIAL LIBRARIES
Document Type and Number:
WIPO Patent Application WO1998033901
Kind Code:
A3
Abstract:
The invention concerns gene banks and combinatorial derivatives thereof, prepared using phagemid- or phage-display in combination with type IIS restriction enzymes and cosmid packaging; their use for the isolation of ligands, including enzyme inhibitors, agonists and antagonists for receptors, competitive binding peptides to a defined target, diagnostic ligands for diseases and autoimmune syndromes, including surveillance tools for immune status, post-translationally modified peptides, and such ligands generated by this technology.
Inventors:
COLLINS JOHN (DE)
ROETTGEN PETER (DE)
ROETTGEN PETER (DE)
Application Number:
PCT/EP1998/000533
Publication Date:
June 17, 1999
Filing Date:
February 02, 1998
Export Citation:
Assignee:
COSMIX MOLECULAR BIOLOG GMBH (DE)
COLLINS JOHN (DE)
ROETTGEN PETER (DE)
COLLINS JOHN (DE)
ROETTGEN PETER (DE)
International Classes:
C07K2/00; C12N15/10; C12N15/09; C40B40/02; (IPC1-7): C12N15/10; C12N15/70
Domestic Patent References:
| WO1992006176A1 | 1992-04-16 | |||
| WO1992006204A1 | 1992-04-16 | |||
| WO1995021914A1 | 1995-08-17 | |||
| WO1996035781A1 | 1996-11-14 |
Foreign References:
| EP0699750A1 | 1996-03-06 | |||
| EP0183571A2 | 1986-06-04 |
Other References:
"IN A NUT SHELL", XP002074514, Retrieved from the Internet [retrieved on 19980813]
SZYBALSKI W. ET AL.: "Class-IIS restriction enzymes - a review", GENE, vol. 100, 1991, pages 13 - 26, XP002074512
HOGREFE H.H. ET AL: "Cloning in bacteriophage lambda vector for the display of binding proteins on filamentous phage", GENE, vol. 137, 1993, pages 85 - 91, XP002074513
SZYBALSKI W. ET AL.: "Class-IIS restriction enzymes - a review", GENE, vol. 100, 1991, pages 13 - 26, XP002074512
HOGREFE H.H. ET AL: "Cloning in bacteriophage lambda vector for the display of binding proteins on filamentous phage", GENE, vol. 137, 1993, pages 85 - 91, XP002074513
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