Title:
GENERATION OF NEURAL PROGENITOR CELLS FROM EMBRYONIC STEM CELLS OR INDUCED PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2022/110180
Kind Code:
A1
Abstract:
Provided are methods, cell culture media and compositions for generating neural progenitor cells (NPCs), particularly human neural progenitor cells (hNPCs) from either human embryonic stem cells (hESCs) or human induced pluripotent stem cells (hiPSCs), wherein the NPCs are particularly suitable for pre-clinical and clinical use.
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| WO/1998/039415 | ESTABLISHED MICROGLIA |
Inventors:
FAN JING (CN)
WANG ANXIN (CN)
REN FANG (CN)
LIU QIANYUN (CN)
ZOU TAN (CN)
WANG ANXIN (CN)
REN FANG (CN)
LIU QIANYUN (CN)
ZOU TAN (CN)
Application Number:
PCT/CN2020/132867
Publication Date:
June 02, 2022
Filing Date:
November 30, 2020
Export Citation:
Assignee:
ZHEJIANG HUODE BIOENGINEERING COMPANY LTD (CN)
International Classes:
C12N5/079
Domestic Patent References:
| WO2019174535A1 | 2019-09-19 |
Foreign References:
| CN108048400A | 2018-05-18 |
Other References:
XU， J. C. ET AL.: "Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity", SCIENCE TRANSLATIONAL MEDICINE, vol. 8, no. 333, 6 April 2016 (2016-04-06), XP055791048, DOI: 10.1126/scitranslmed.aad0623
CHANDRASEKARAN， A. ET AL.: "Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells", STEM CELL RESERACH, vol. 25, 14 October 2017 (2017-10-14), pages 139 - 151, XP085305653, DOI: 10.1016/j.scr.2017.10.010
BELL SCOTT, HETTIGE NUWAN, SILVEIRA HEIKA, PENG HUASHAN, WU HANRONG, JEFRI MALVIN, ANTONYAN LILIT, ZHANG YING, ZHANG XIN, ERNST CA: "Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) into an Effective Model of Forebrain Neural Progenitor Cells and Mature Neurons", BIO-PROTOCOL, BIO-PROTOCOL.ORG, SUNNYVALE, CA, USA, vol. 9, no. 5, 1 January 2019 (2019-01-01), Sunnyvale, CA, USA , XP055932504, ISSN: 2331-8325, DOI: 10.21769/BioProtoc.3188
MEIXIANG ZHANG, JUSTINE NGO, FILOMENA PIROZZI, YING-PU SUN, ANTHONY WYNSHAW-BORIS: "Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells", STEM CELL RESEARCH & THERAPY, vol. 9, no. 1, 1 December 2018 (2018-12-01), XP055698226, DOI: 10.1186/s13287-018-0812-6
CHANDRASEKARAN， A. ET AL.: "Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells", STEM CELL RESERACH, vol. 25, 14 October 2017 (2017-10-14), pages 139 - 151, XP085305653, DOI: 10.1016/j.scr.2017.10.010
BELL SCOTT, HETTIGE NUWAN, SILVEIRA HEIKA, PENG HUASHAN, WU HANRONG, JEFRI MALVIN, ANTONYAN LILIT, ZHANG YING, ZHANG XIN, ERNST CA: "Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) into an Effective Model of Forebrain Neural Progenitor Cells and Mature Neurons", BIO-PROTOCOL, BIO-PROTOCOL.ORG, SUNNYVALE, CA, USA, vol. 9, no. 5, 1 January 2019 (2019-01-01), Sunnyvale, CA, USA , XP055932504, ISSN: 2331-8325, DOI: 10.21769/BioProtoc.3188
MEIXIANG ZHANG, JUSTINE NGO, FILOMENA PIROZZI, YING-PU SUN, ANTHONY WYNSHAW-BORIS: "Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells", STEM CELL RESEARCH & THERAPY, vol. 9, no. 1, 1 December 2018 (2018-12-01), XP055698226, DOI: 10.1186/s13287-018-0812-6
Attorney, Agent or Firm:
IPFAITH PARTNERS (CN)
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