Title:
GENES IDENTIFIED AS REQUIRED FOR PROLIFERATION OF E. COLI
Document Type and Number:
WIPO Patent Application WO2001048209
Kind Code:
B1
Abstract:
The sequences of nucleic acids encoding proteins required for E. coli proliferation are disclosed. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than E. coli. The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids of the present invention can also be used in various assay systems to screen for antimicrobial agents.
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Inventors:
FORSYTH R ALLYN (US)
OHLSEN KARI L (US)
ZYSKIND JUDITH W (US)
OHLSEN KARI L (US)
ZYSKIND JUDITH W (US)
Application Number:
PCT/US2000/034419
Publication Date:
June 06, 2002
Filing Date:
December 19, 2000
Export Citation:
Assignee:
ELITRA PHARMACEUTICALS INC (US)
FORSYTH R ALLYN (US)
OHLSEN KARI L (US)
ZYSKIND JUDITH W (US)
FORSYTH R ALLYN (US)
OHLSEN KARI L (US)
ZYSKIND JUDITH W (US)
International Classes:
G01N33/53; A61K31/7088; A61K45/00; A61K48/00; A61P31/04; A61P31/10; A61P43/00; C07K14/195; C07K14/245; C07K16/12; C12N1/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/31; C12P21/02; C12Q1/02; C12Q1/18; C12Q1/25; G01N33/15; G01N33/566; C12R1/68; (IPC1-7): C12N15/31; C12N15/11; C12N15/10; C07K14/245
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