Title:
GENES
Document Type and Number:
WIPO Patent Application WO2003056036
Kind Code:
A3
Abstract:
The invention relates to mutations in B-Raf gene products. The mutations described are identified in human tumours of natural origin. These mutations are associated with cancerous phenotypes and can be used as a basis for the diagnosis of cancer, cancerous cells or a predisposition to cancer in human subjects, and the development of anti-cancer therapeutics.
Inventors:
STRATTON MIKE (GB)
FUTREAL ANDY (GB)
WOOSTER RICHARD (GB)
MARAIS RICHARD MALCOLM (GB)
MARSHALL CHRIS (GB)
FUTREAL ANDY (GB)
WOOSTER RICHARD (GB)
MARAIS RICHARD MALCOLM (GB)
MARSHALL CHRIS (GB)
Application Number:
PCT/GB2002/005891
Publication Date:
December 31, 2003
Filing Date:
December 23, 2002
Export Citation:
Assignee:
WELLCOME TRUST (GB)
STRATTON MIKE (GB)
FUTREAL ANDY (GB)
WOOSTER RICHARD (GB)
MARAIS RICHARD MALCOLM (GB)
MARSHALL CHRIS (GB)
STRATTON MIKE (GB)
FUTREAL ANDY (GB)
WOOSTER RICHARD (GB)
MARAIS RICHARD MALCOLM (GB)
MARSHALL CHRIS (GB)
International Classes:
C07H21/04; C12N9/10; C12Q1/68; (IPC1-7): C12N9/12; C12Q1/68; C07K16/40; C12Q1/48
Domestic Patent References:
| WO1999002167A1 | 1999-01-21 | |||
| WO1997040184A1 | 1997-10-30 | |||
| WO1998047077A1 | 1998-10-22 | |||
| WO2001013111A2 | 2001-02-22 | |||
| WO1999032106A1 | 1999-07-01 | |||
| WO1998022103A1 | 1998-05-28 |
Other References:
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 9 April 1996 (1996-04-09), IKAWA, S. ET AL.: "Human B-raf oncogene mRNA, 3' end", XP002249540, retrieved from US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, M accession no. M21001 Database accession no. gi:179534
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 27 April 1993 (1993-04-27), SITHANANDAM, G. ET AL.: "Human B-raf mRNA, complete cds", XP002249539, retrieved from US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, M accession no. M95712 Database accession no. gi:179532
DATABASE EMBL [online] EBI; 15 June 1992 (1992-06-15), SITHANANDAM, G. ET AL.: "Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies", XP002256147, retrieved from EBI accession no. HSBRAF3 Database accession no. HSBRAF3
MACNICOL M C ET AL: "Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 11 FEB 2000, vol. 275, no. 6, 11 February 2000 (2000-02-11), pages 3803 - 3809, XP002249537, ISSN: 0021-9258
OKADA TOMOYO ET AL: "The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 9, 1999, pages 6057 - 6064, XP002249538, ISSN: 0270-7306
WHITEHOUSE D B ET AL: "PROTEIN PROFILING WITH ALLELE-SPECIFIC ANTIBODIES", PROGRESS IN FORENSIC GENETICS, XX, XX, vol. 8, no. 1193, 2000, pages 412 - 415, XP000981339
GUAN KUN-LIANG ET AL: "Negative regulation of the serine/threonine kinase B-Raf by Akt.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 35, 1 September 2000 (2000-09-01), pages 27354 - 27359, XP002256144, ISSN: 0021-9258
PAPIN C ET AL: "Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 18 SEP 1998, vol. 273, no. 38, 18 September 1998 (1998-09-18), pages 24939 - 24947, XP002256145, ISSN: 0021-9258
ALESSI D R ET AL: "Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.", METHODS IN ENZYMOLOGY. UNITED STATES 1995, vol. 255, 1995, pages 279 - 290, XP008022766, ISSN: 0076-6879
SEBOLT-LEOPOLD J S: "Development of anticancer drugs targeting the MAP kinase pathway.", ONCOGENE. ENGLAND 27 DEC 2000, vol. 19, no. 56, 27 December 2000 (2000-12-27), pages 6594 - 6599, XP002250479, ISSN: 0950-9232
YEUNG KAM ET AL: "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the Raf kinase inhibitor protein.", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 9, May 2000 (2000-05-01), pages 3079 - 3085, XP002256146, ISSN: 0270-7306
LYONS J F ET AL: "Discovery of a novel Raf kinase inhibitor.", ENDOCRINE-RELATED CANCER. ENGLAND SEP 2001, vol. 8, no. 3, September 2001 (2001-09-01), pages 219 - 225, XP008022717, ISSN: 1351-0088
MONIA B P ET AL: "Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 24 DEC 1996, vol. 93, no. 26, 24 December 1996 (1996-12-24), pages 15481 - 15484, XP002073792, ISSN: 0027-8424
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; 27 April 1993 (1993-04-27), SITHANANDAM, G. ET AL.: "Human B-raf mRNA, complete cds", XP002249539, retrieved from US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, M accession no. M95712 Database accession no. gi:179532
DATABASE EMBL [online] EBI; 15 June 1992 (1992-06-15), SITHANANDAM, G. ET AL.: "Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies", XP002256147, retrieved from EBI accession no. HSBRAF3 Database accession no. HSBRAF3
MACNICOL M C ET AL: "Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 11 FEB 2000, vol. 275, no. 6, 11 February 2000 (2000-02-11), pages 3803 - 3809, XP002249537, ISSN: 0021-9258
OKADA TOMOYO ET AL: "The strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPases.", MOLECULAR AND CELLULAR BIOLOGY, vol. 19, no. 9, 1999, pages 6057 - 6064, XP002249538, ISSN: 0270-7306
WHITEHOUSE D B ET AL: "PROTEIN PROFILING WITH ALLELE-SPECIFIC ANTIBODIES", PROGRESS IN FORENSIC GENETICS, XX, XX, vol. 8, no. 1193, 2000, pages 412 - 415, XP000981339
GUAN KUN-LIANG ET AL: "Negative regulation of the serine/threonine kinase B-Raf by Akt.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 35, 1 September 2000 (2000-09-01), pages 27354 - 27359, XP002256144, ISSN: 0021-9258
PAPIN C ET AL: "Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. UNITED STATES 18 SEP 1998, vol. 273, no. 38, 18 September 1998 (1998-09-18), pages 24939 - 24947, XP002256145, ISSN: 0021-9258
ALESSI D R ET AL: "Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf.", METHODS IN ENZYMOLOGY. UNITED STATES 1995, vol. 255, 1995, pages 279 - 290, XP008022766, ISSN: 0076-6879
SEBOLT-LEOPOLD J S: "Development of anticancer drugs targeting the MAP kinase pathway.", ONCOGENE. ENGLAND 27 DEC 2000, vol. 19, no. 56, 27 December 2000 (2000-12-27), pages 6594 - 6599, XP002250479, ISSN: 0950-9232
YEUNG KAM ET AL: "Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the Raf kinase inhibitor protein.", MOLECULAR AND CELLULAR BIOLOGY, vol. 20, no. 9, May 2000 (2000-05-01), pages 3079 - 3085, XP002256146, ISSN: 0270-7306
LYONS J F ET AL: "Discovery of a novel Raf kinase inhibitor.", ENDOCRINE-RELATED CANCER. ENGLAND SEP 2001, vol. 8, no. 3, September 2001 (2001-09-01), pages 219 - 225, XP008022717, ISSN: 1351-0088
MONIA B P ET AL: "Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 24 DEC 1996, vol. 93, no. 26, 24 December 1996 (1996-12-24), pages 15481 - 15484, XP002073792, ISSN: 0027-8424
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