Title:
GENETIC DIAGNOSIS FOR DISEASES WHEREIN TNF-$g(a) PROMOTER PARTICIPATES
Document Type and Number:
WIPO Patent Application WO/1998/054309
Kind Code:
A1
Abstract:
Changes in nucleotide(s) at the -857, -863 and/or -1031 position in the 5' flanking region of a TNF-$g(a) gene is measured to genetically diagnose diseases wherein TNF-$g(a) promoter participates, such as juvenile rheumatoid arthritis.
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Inventors:
KAMIZONO SHINTARO (JP)
YAMADA AKIRA (JP)
HIGUCHI TAKAFUMI (JP)
KATO HIROHISA (JP)
ITOH KYOGO (JP)
YAMADA AKIRA (JP)
HIGUCHI TAKAFUMI (JP)
KATO HIROHISA (JP)
ITOH KYOGO (JP)
Application Number:
PCT/JP1997/004304
Publication Date:
December 03, 1998
Filing Date:
November 26, 1997
Export Citation:
Assignee:
SHIONOGI & CO (JP)
KAMIZONO SHINTARO (JP)
YAMADA AKIRA (JP)
HIGUCHI TAKAFUMI (JP)
KATO HIROHISA (JP)
ITOH KYOGO (JP)
KAMIZONO SHINTARO (JP)
YAMADA AKIRA (JP)
HIGUCHI TAKAFUMI (JP)
KATO HIROHISA (JP)
ITOH KYOGO (JP)
International Classes:
C12N15/12; C12Q1/68; (IPC1-7): C12N15/00; C12Q1/68; A61K45/00; G01N33/564
Other References:
TISSUE ANTIGENS, Vol. 49, (Jan. 1997), J. VINASCO et al., "Polymorphism at the TNF Loci in Rheumatoid Arthritis", p. 74-78.
GENE, Vol. 131, (1993), S. TAKASHIBA et al., "Cloning and Characterization of Human TNF alpha Promoter Region", p. 307-308.
GENE, Vol. 131, (1993), S. TAKASHIBA et al., "Cloning and Characterization of Human TNF alpha Promoter Region", p. 307-308.
Attorney, Agent or Firm:
Aoyama, Tamotsu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka 540, JP)
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