Title:
GENETIC ENGINEERING OF FUNGI TO MODULATE TRYPTAMINE EXPRESSION
Document Type and Number:
WIPO Patent Application WO/2021/067626
Kind Code:
A3
Abstract:
Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psi!ocin compositions generated by the provided methods.
Inventors:
HENLEY THOMAS (US)
CHOUDHRY MODASSIR (US)
FERNANDEZ-GOMEZ JOSE (US)
CHOUDHRY MODASSIR (US)
FERNANDEZ-GOMEZ JOSE (US)
Application Number:
PCT/US2020/053842
Publication Date:
May 14, 2021
Filing Date:
October 01, 2020
Export Citation:
Assignee:
INTIMA BIOSCIENCE INC (US)
International Classes:
C12N15/63; C12N9/10; C12N15/82
Domestic Patent References:
| WO2019180309A1 | 2019-09-26 | |||
| WO2019173797A1 | 2019-09-12 |
Other References:
SUGANO ET AL.: "Genome editing in the mushroom-forming basidiomycete Coprinopsis cinerea, optimized by a high throughput transformation system", SCIENTIFIC REPORTS, vol. 7, no. 1, 28 April 2017 (2017-04-28), XP055622319, DOI: 10.1038/s41598-017-00883-5
DATABASE GenBank [online] 26 August 2017 (2017-08-26), "Psilocybe cubensis strain FSU 12409 tryptophan decarboxylase (psiD) mRNA, complete cds", XP055822398, Database accession no. KY984101
DATABASE GenBank [online] 26 August 2017 (2017-08-26), "Psilocybe cubensis strain FSU 12409 tryptophan decarboxylase (psiD) mRNA, complete cds", XP055822398, Database accession no. KY984101
Attorney, Agent or Firm:
WANG, YINGJIAO (US)
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