Title:
GENETIC POLYMORPHISMS AS PREDICTIVE DIAGNOSTICS FOR ADVERSE DRUG REACTIONS (ADR) AND DRUG EFFICACY
Document Type and Number:
WIPO Patent Application WO2004069867
Kind Code:
A3
Abstract:
The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.
Inventors:
STROPP UDO (DE)
SCHWERS STEPHAN (DE)
KALLABIS HARALD (DE)
SCHMITZ GERD (DE)
SCHWERS STEPHAN (DE)
KALLABIS HARALD (DE)
SCHMITZ GERD (DE)
Application Number:
PCT/EP2004/000884
Publication Date:
March 24, 2005
Filing Date:
January 31, 2004
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
STROPP UDO (DE)
SCHWERS STEPHAN (DE)
KALLABIS HARALD (DE)
SCHMITZ GERD (DE)
STROPP UDO (DE)
SCHWERS STEPHAN (DE)
KALLABIS HARALD (DE)
SCHMITZ GERD (DE)
International Classes:
A61K38/17; C07K14/47; C07K14/715; C07K14/81; C12Q1/68; A61K38/00; (IPC1-7): C07K14/47; A61K38/17; C12Q1/68
Domestic Patent References:
| WO1999014363A1 | 1999-03-25 | |||
| WO1998040517A1 | 1998-09-17 | |||
| WO2001002606A2 | 2001-01-11 |
Foreign References:
| EP1327639A1 | 2003-07-16 |
Other References:
YAMADA Y ET AL: "Prediction of the risk of myocardial infarction from polymorphisms in candidate genes", NEW ENGLAND JOURNAL OF MEDICINE, vol. 347, no. 24, 12 December 2002 (2002-12-12), pages 1916 - 1923, XP002971561, ISSN: 0028-4793
CAMBIEN F ET AL: "Sequence diversity in 36 candidate genes for cardiovascular disorders", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 65, no. 1, July 1999 (1999-07-01), pages 183 - 191, XP000920770, ISSN: 0002-9297
NORDT TK ET AL: "Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis", THROMBOSIS RESEARCH, vol. 103, no. Supplement 1, 30 September 2001 (2001-09-30), pages S1 - S5, XP002286005, ISSN: 0049-3848
OSSEI-GERNING N ET AL: "Plasminogen activator inhibitor-I promoter 4G/5G genotype and plasma levels in relation to a history of myocardial infarction in patients characterized by coronary angiography", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 17, no. 1, 1997, pages 33 - 37, XP002041862, ISSN: 1079-5642
CAMBIEN F ET AL: "Sequence diversity in 36 candidate genes for cardiovascular disorders", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 65, no. 1, July 1999 (1999-07-01), pages 183 - 191, XP000920770, ISSN: 0002-9297
NORDT TK ET AL: "Regulation of PAI-1 expression by genetic polymorphisms. Impact on atherogenesis", THROMBOSIS RESEARCH, vol. 103, no. Supplement 1, 30 September 2001 (2001-09-30), pages S1 - S5, XP002286005, ISSN: 0049-3848
OSSEI-GERNING N ET AL: "Plasminogen activator inhibitor-I promoter 4G/5G genotype and plasma levels in relation to a history of myocardial infarction in patients characterized by coronary angiography", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 17, no. 1, 1997, pages 33 - 37, XP002041862, ISSN: 1079-5642
Download PDF:
Previous Patent: CONTROL OF PLANT GROWTH AND DEVELOPMENTAL PROCESSES
Next Patent: COMPLEX OF TELOMERE PROTEIN WITH GUANINE-QUADRUPLEX DNA
Next Patent: COMPLEX OF TELOMERE PROTEIN WITH GUANINE-QUADRUPLEX DNA