Title:
GENETIC PREDICTORS OF RESPONSE TO TREATMENT WITH CRHR1 ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2013/160315
Kind Code:
A3
Abstract:
The invention relates inter alia to methods for predicting the response of patients with depressive symptoms and/or anxiety symptoms to treatment with a CRHR1 antagonist, and algorithms, kits, microarrays, probes and or/primers for use in such methods.
Inventors:
MUELLER-MYHSOK BERTRAM (DE)
BINDER ELISABETH (DE)
HOLSBOER FLORIAN (DE)
BINDER ELISABETH (DE)
HOLSBOER FLORIAN (DE)
Application Number:
PCT/EP2013/058411
Publication Date:
January 03, 2014
Filing Date:
April 23, 2013
Export Citation:
Assignee:
MAX PLANCK GESELLSCHAFT (DE)
International Classes:
C12Q1/68; G16H50/20
Domestic Patent References:
| WO2006017854A2 | 2006-02-16 | |||
| WO2009113985A1 | 2009-09-17 |
Foreign References:
| US20050069936A1 | 2005-03-31 |
Other References:
TYRKA A R ET AL: "Interaction of Childhood Maltreatment with the Corticotropin-Releasing Hormone Receptor Gene: Effects on Hypothalamic-Pituitary-Adrenal Axis Reactivity", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY; US, vol. 66, no. 7, 1 October 2009 (2009-10-01), pages 681 - 685, XP026583738, ISSN: 0006-3223, [retrieved on 20090712], DOI: 10.1016/J.BIOPSYCH.2009.05.012
THODE KIRSTIN I ET AL: "Hypothalamic-pituitary-adrenal axis activation in response to stress is moderated by polymorphic variants within the corticotropin-releasing hormone receptor 1", BIOLOGICAL PSYCHIATRY, vol. 63, no. 7, Suppl. S, April 2008 (2008-04-01), & 63RD ANNUAL CONVENTION OF THE SOCIETY-OF-BIOLOGICAL-PSYCHIATRY; WASHINGTON, DC, USA; 2008,, pages 85S, XP002711334, ISSN: 0006-3223
LIU Z ET AL: "Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression", NEUROSCIENCE LETTERS, LIMERICK, IE, vol. 404, no. 3, 1 September 2006 (2006-09-01), pages 358 - 362, XP027885387, ISSN: 0304-3940, [retrieved on 20060901]
LIU ET AL: "Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders", NEUROSCIENCE LETTERS, LIMERICK, IE, vol. 414, no. 2, 20 February 2007 (2007-02-20), pages 155 - 158, XP005896303, ISSN: 0304-3940, DOI: 10.1016/J.NEULET.2006.12.013
LICINIO J ET AL: "Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans", MOLECULAR PSYCHIATRY, BASINGSTOKE, GB, vol. 9, no. 12, 1 January 2004 (2004-01-01), pages 1075 - 1082, XP002540580, ISSN: 1359-4184, [retrieved on 20040914], DOI: 10.1038/SJ.MP.4001587
BROUWER J P ET AL: "Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression", PSYCHONEUROENDOCRINOLOGY, OXFORD, GB, vol. 31, no. 10, 1 November 2006 (2006-11-01), pages 1154 - 1163, XP027955755, ISSN: 0306-4530, [retrieved on 20061101]
VAN ROSSUM ET AL: "Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY; US, vol. 59, no. 8, 15 April 2006 (2006-04-15), pages 681 - 688, XP005358072, ISSN: 0006-3223, DOI: 10.1016/J.BIOPSYCH.2006.02.007
MARCUS ISING: "A Genomewide Association Study Points to Multiple Loci That Predict Antidepressant Drug Treatment Outcome in DepressionAntidepressant Drug Treatment Outcome ", ARCHIVES OF GENERAL PSYCHIATRY, vol. 66, no. 9, 1 September 2009 (2009-09-01), pages 966, XP055075165, ISSN: 0003-990X, DOI: 10.1001/archgenpsychiatry.2009.95
STEPHAN RIPKE ET AL: "A mega-analysis of genome-wide association studies for major depressive disorder", MOLECULAR PSYCHIATRY, vol. 18, no. 4, 3 April 2012 (2012-04-03), pages 497 - 511, XP055075174, ISSN: 1359-4184, DOI: 10.1038/mp.2012.21
CONCETTA CRISAFULLI ET AL: "Pharmacogenetics of Antidepressants", FRONTIERS IN PHARMACOLOGY, vol. 2, 1 January 2011 (2011-01-01), pages 6 - 6, XP055075188, ISSN: 1663-9812, DOI: 10.3389/fphar.2011.00006
THODE KIRSTIN I ET AL: "Hypothalamic-pituitary-adrenal axis activation in response to stress is moderated by polymorphic variants within the corticotropin-releasing hormone receptor 1", BIOLOGICAL PSYCHIATRY, vol. 63, no. 7, Suppl. S, April 2008 (2008-04-01), & 63RD ANNUAL CONVENTION OF THE SOCIETY-OF-BIOLOGICAL-PSYCHIATRY; WASHINGTON, DC, USA; 2008,, pages 85S, XP002711334, ISSN: 0006-3223
LIU Z ET AL: "Association of corticotropin-releasing hormone receptor1 gene SNP and haplotype with major depression", NEUROSCIENCE LETTERS, LIMERICK, IE, vol. 404, no. 3, 1 September 2006 (2006-09-01), pages 358 - 362, XP027885387, ISSN: 0304-3940, [retrieved on 20060901]
LIU ET AL: "Association study of corticotropin-releasing hormone receptor1 gene polymorphisms and antidepressant response in major depressive disorders", NEUROSCIENCE LETTERS, LIMERICK, IE, vol. 414, no. 2, 20 February 2007 (2007-02-20), pages 155 - 158, XP005896303, ISSN: 0304-3940, DOI: 10.1016/J.NEULET.2006.12.013
LICINIO J ET AL: "Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans", MOLECULAR PSYCHIATRY, BASINGSTOKE, GB, vol. 9, no. 12, 1 January 2004 (2004-01-01), pages 1075 - 1082, XP002540580, ISSN: 1359-4184, [retrieved on 20040914], DOI: 10.1038/SJ.MP.4001587
BROUWER J P ET AL: "Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression", PSYCHONEUROENDOCRINOLOGY, OXFORD, GB, vol. 31, no. 10, 1 November 2006 (2006-11-01), pages 1154 - 1163, XP027955755, ISSN: 0306-4530, [retrieved on 20061101]
VAN ROSSUM ET AL: "Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression", BIOLOGICAL PSYCHIATRY, ELSEVIER SCIENCE, NEW YORK, NY; US, vol. 59, no. 8, 15 April 2006 (2006-04-15), pages 681 - 688, XP005358072, ISSN: 0006-3223, DOI: 10.1016/J.BIOPSYCH.2006.02.007
MARCUS ISING: "A Genomewide Association Study Points to Multiple Loci That Predict Antidepressant Drug Treatment Outcome in Depression
STEPHAN RIPKE ET AL: "A mega-analysis of genome-wide association studies for major depressive disorder", MOLECULAR PSYCHIATRY, vol. 18, no. 4, 3 April 2012 (2012-04-03), pages 497 - 511, XP055075174, ISSN: 1359-4184, DOI: 10.1038/mp.2012.21
CONCETTA CRISAFULLI ET AL: "Pharmacogenetics of Antidepressants", FRONTIERS IN PHARMACOLOGY, vol. 2, 1 January 2011 (2011-01-01), pages 6 - 6, XP055075188, ISSN: 1663-9812, DOI: 10.3389/fphar.2011.00006
Attorney, Agent or Firm:
MAIWALD PATENTANWALTS GMBH (MartinElisenho, Elisenstrasse 3 München, DE)
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