Title:
GENETIC SWITCHES FOR BUTANOL PRODUCTION
Document Type and Number:
WIPO Patent Application WO/2013/102147
Kind Code:
A3
Abstract:
The invention relates to suitable screening strategies for evaluating various candidate promoters for differential gene expression during the propagation and production phases of a fermentation process. The invention also relates to recombinant host cells that comprise identified promoter nucleic acid sequences and methods for producing fermentation products employing the same.
Inventors:
DAUNER MICHAEL (US)
KRUCKEBERG ARTHUR LEO (US)
LAROSSA ROBERT A (US)
PAUL BRIAN JAMES (US)
TUMINELLO JOSEPH FREDERICH (US)
SUH WONCHUL (US)
KRUCKEBERG ARTHUR LEO (US)
LAROSSA ROBERT A (US)
PAUL BRIAN JAMES (US)
TUMINELLO JOSEPH FREDERICH (US)
SUH WONCHUL (US)
Application Number:
PCT/US2012/072186
Publication Date:
October 17, 2013
Filing Date:
December 28, 2012
Export Citation:
Assignee:
BUTAMAX TM ADVANCED BIOFUELS (US)
International Classes:
C12P7/16; C12N15/67; C12P7/26
Domestic Patent References:
| WO2008144060A2 | 2008-11-27 |
Foreign References:
| US20070092957A1 | 2007-04-26 |
Other References:
SCOTCHER MILES C ET AL: "Expression of abrB310 and SinR, and effects of decreased abrB310 expression on the transition from acidogenesis to solventogenesis, in Clostridium acetobutylicum ATCC 824.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 71, no. 4, April 2005 (2005-04-01), pages 1987 - 1995, XP002698023, ISSN: 0099-2240
BRINK, J.; P. DARAN-LAPUJADE ET AL.: "New insights into the Saccharomyces cerevisiae fermentation switch: dynamic transcriptional response to anaerobicity and glucose-excess", BMC GENOMICS, vol. 9, 100, 27 February 2008 (2008-02-27), pages 14PP, XP021032820
RINTALA, E., M.; G. WIEBE ET AL.: "Transcription of hexose transporters of Saccharomyces cerevisiae is affected by change in oxygen provision", BMC MICROBIOLOGY, vol. 1 8, 53, 28 March 2008 (2008-03-28), pages 12PP, XP021033354
HOLGER JANSSEN ET AL: "A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 87, no. 6, 9 July 2010 (2010-07-09), SPRINGER, BERLIN, DE, pages 2209 - 2226, XP019841739, ISSN: 1432-0614
GRIMMLER CHRISTINA ET AL: "Genome-wide gene expression analysis of the switch between acidogenesis and solventogenesis in continuous cultures of Clostridium acetobutylicum.", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, vol. 20, no. 1, 6 January 2011 (2011-01-06), pages 1 - 15, XP002698026, ISSN: 1660-2412
MAO SHAOMING ET AL: "Proteome reference map and comparative proteomic analysis between a wild type Clostridium acetobutylicum DSM 1731 and its mutant with enhanced butanol tolerance and butanol yield.", JOURNAL OF PROTEOME RESEARCH, vol. 9, no. 6, 4 June 2010 (2010-06-04), pages 3046 - 3061, XP002698027, ISSN: 1535-3907
AMADOR-NOGUEZ DANIEL ET AL: "Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 77, no. 22, November 2011 (2011-11-01), pages 7984 - 7997, XP002698028, ISSN: 1098-5336
BRINK, J.; P. DARAN-LAPUJADE ET AL.: "New insights into the Saccharomyces cerevisiae fermentation switch: dynamic transcriptional response to anaerobicity and glucose-excess", BMC GENOMICS, vol. 9, 100, 27 February 2008 (2008-02-27), pages 14PP, XP021032820
RINTALA, E., M.; G. WIEBE ET AL.: "Transcription of hexose transporters of Saccharomyces cerevisiae is affected by change in oxygen provision", BMC MICROBIOLOGY, vol. 1 8, 53, 28 March 2008 (2008-03-28), pages 12PP, XP021033354
HOLGER JANSSEN ET AL: "A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 87, no. 6, 9 July 2010 (2010-07-09), SPRINGER, BERLIN, DE, pages 2209 - 2226, XP019841739, ISSN: 1432-0614
GRIMMLER CHRISTINA ET AL: "Genome-wide gene expression analysis of the switch between acidogenesis and solventogenesis in continuous cultures of Clostridium acetobutylicum.", JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, vol. 20, no. 1, 6 January 2011 (2011-01-06), pages 1 - 15, XP002698026, ISSN: 1660-2412
MAO SHAOMING ET AL: "Proteome reference map and comparative proteomic analysis between a wild type Clostridium acetobutylicum DSM 1731 and its mutant with enhanced butanol tolerance and butanol yield.", JOURNAL OF PROTEOME RESEARCH, vol. 9, no. 6, 4 June 2010 (2010-06-04), pages 3046 - 3061, XP002698027, ISSN: 1535-3907
AMADOR-NOGUEZ DANIEL ET AL: "Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum.", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 77, no. 22, November 2011 (2011-11-01), pages 7984 - 7997, XP002698028, ISSN: 1098-5336
Attorney, Agent or Firm:
LHULIER, Christine, M. (Legal Patent Records Center4417 Lancaster Pik, Wilmington DE, US)
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