Title:
GENETICALLY-MODIFIED CELLS AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2018/052142
Kind Code:
A1
Abstract:
The purpose of the present invention is to produce chimeric antigen receptor (CAR)-expressing cells having superior target cell cytotoxicity. Provided are genetically-modified cells obtained by introducing polynucleotides that encode chimeric antigen receptor (CAR) proteins comprising a target binding domain that specifically binds to human granulocyte-macrophage colony-stimulating factor (GM-CSF), a transmembrane domain, and an intercellular signaling domain.
Inventors:
NAKAZAWA YOZO (JP)
MATSUDA KAZUYUKI (JP)
NAKANO SHIGERU (JP)
MATSUDA KAZUYUKI (JP)
NAKANO SHIGERU (JP)
Application Number:
PCT/JP2017/033582
Publication Date:
March 22, 2018
Filing Date:
September 15, 2017
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
UNIV SHINSHU (JP)
UNIV SHINSHU (JP)
International Classes:
C12N15/09; A61K31/7088; A61K35/12; A61K48/00; A61P43/00; C07K14/535; C07K19/00; C12N5/10; C12N15/113
Domestic Patent References:
| WO2015124715A1 | 2015-08-27 | |||
| WO2015066262A1 | 2015-05-07 | |||
| WO2017061615A1 | 2017-04-13 |
Foreign References:
| JPS63502795A | 1988-10-20 |
Other References:
NAKAZAWA, YOZO ET AL.: "Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD 116 on CD 34+ cells of juvenile myelomonocytic leukemia", J. HEMATOL. ONCOL, vol. 9, no. 27, 16 March 2016 (2016-03-16), pages 1 - 11, XP002758093, DOI: 10.1186/s13045-016-0256-3
NAKANO, SHIGERU ET AL.: "Ligand-based chimeric antigen receptor-modified T cells targeting CD 116 for the treatment of acute myeloid leukemia", THE 22ND ANNUAL MEETING JSGCT2016: JAPAN SOCIETY OF GENE AND CELL THERAPY PROGRAM AND ABSTRACTS, 13 July 2016 (2016-07-13)
SHAFFER, DONALD R. ET AL.: "Foreign or Domestic CARs: Receptor Ligands as Antigen-Binding Domains", MED. SCI., vol. 2, 2014, pages 23 - 36, XP002742098, DOI: doi:10.3390/medsci2010023
NAKAZAWA, YOZO: "Treatment of childhood cancer by genetically modified t-cells", JAPANESE JOURNAL OF PEDIATRIC MEDICINE, vol. 49, 1 July 2017 (2017-07-01), pages 1017 - 1023
NAKANO, SHIGERU ET AL.: "Ligand-based chimeric antigen receptor-modified T cells targeting CD 116 for the treatment of acute myeloid leukemia", THE 22ND ANNUAL MEETING JSGCT2016: JAPAN SOCIETY OF GENE AND CELL THERAPY PROGRAM AND ABSTRACTS, 13 July 2016 (2016-07-13)
SHAFFER, DONALD R. ET AL.: "Foreign or Domestic CARs: Receptor Ligands as Antigen-Binding Domains", MED. SCI., vol. 2, 2014, pages 23 - 36, XP002742098, DOI: doi:10.3390/medsci2010023
NAKAZAWA, YOZO: "Treatment of childhood cancer by genetically modified t-cells", JAPANESE JOURNAL OF PEDIATRIC MEDICINE, vol. 49, 1 July 2017 (2017-07-01), pages 1017 - 1023
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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