GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC BTLA

Title:

GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC BTLA

Document Type and Number:

WIPO Patent Application WO/2018/068756

Kind Code:

A1

Abstract:

Genetically modified non-human animals that express a human or chimeric (e.g., humanized) B-and T-Lymphocyte-Associated Protein (BTLA or CD272), and methods of use thereof are provided.

Inventors:

SHEN YUELEI (CN)
BAI YANG (CN)
GUO YANAN (CN)
HUANG RUI (CN)
ZHOU XIAOFEI (CN)
ZHANG MEILING (CN)

Application Number:

PCT/CN2017/106024

Publication Date:

April 19, 2018

Filing Date:

October 13, 2017

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Assignee:

BEIJING BIOCYTOGEN CO LTD (CN)

International Classes:

C12N15/85; A01K67/027; A61K39/395; A61P35/00; C07K14/705; C12N15/113; C12N15/12; C12N15/90

Foreign References:

CN101578296A

2009-11-11

Other References:

DATABASE Protein [O] 1 September 2016 (2016-09-01), GHAZAVI F ET AL.: "B- and t-lymphocyte attenuator isoform 1 precursor[Homo sapiens", XP055502209, Database accession no. NP_861445
DATABASE Nucleotide [O] 18 June 2003 (2003-06-18), WATANABE ET AL.: "Mus musculus B and T lymphocyte attenuator(Btla) mRNA. complete cds", XP055502212, Database accession no. AY293285
DATABASE Nucleotide [O] 1 September 2016 (2016-09-01), BRELOER M ET AL.: "Mus musculus B and T lymphocyte attenuator(Btla), transcript variant 1, mRNA", XP055502213, Database accession no. NM_001037719
DATABASE Protein [O] 4 October 2006 (2006-10-04), STRUSBERG, R.L. ET AL.: "Btla protein[Mus musculus", XP055502217, Database accession no. AAI08965

Attorney, Agent or Firm:

BEIJING ZJWT PATENT AGENCY CO., LTD. (CN)

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