Title:
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD94 AND/OR NKG2A
Document Type and Number:
WIPO Patent Application WO/2021/233438
Kind Code:
A1
Abstract:
Provided are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD94 and/or NKG2A, and methods of use thereof.
Inventors:
SHEN YUELEI (CN)
BAI YANG (CN)
GUO CHAOSHE (CN)
ZHANG MEILING (CN)
HUANG RUI (CN)
SHANG CHENGZHANG (CN)
BAI YANG (CN)
GUO CHAOSHE (CN)
ZHANG MEILING (CN)
HUANG RUI (CN)
SHANG CHENGZHANG (CN)
Application Number:
PCT/CN2021/095255
Publication Date:
November 25, 2021
Filing Date:
May 21, 2021
Export Citation:
Assignee:
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
A61P35/00; A01K67/027; C12N15/09; C12N15/90
Domestic Patent References:
| WO2019072241A1 | 2019-04-18 |
Foreign References:
| CN109136274A | 2019-01-04 | |||
| CN108588126A | 2018-09-28 | |||
| CN109136275A | 2019-01-04 | |||
| CN109136261A | 2019-01-04 | |||
| CN110079529A | 2019-08-02 |
Other References:
ANONYMOUS: "[First New Product] A2AR, CD94, NKG2A are coming!", BIOSSET, 9 September 2020 (2020-09-09), XP055877754, Retrieved from the Internet [retrieved on 20220111]
ANDRÉ PASCALE; DENIS CAROLINE; SOULAS CAROLINE; BOURBON-CAILLET CLARISSE; LOPEZ JULIE; ARNOUX THOMAS; BLÉRY MATHIEU; BONNAFOUS CÉC: "Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells", CELL, ELSEVIER, AMSTERDAM NL, vol. 175, no. 7, 1 January 1900 (1900-01-01), Amsterdam NL , pages 1731, XP085560732, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.014
DATABASE Nucleotide 8 May 2020 (2020-05-08), "Mus musculus killer cell lectin-like receptor, subfamily D, member 1 (Klrd1), mRNA ", XP055877740, retrieved from NCBI Database accession no. NM_010654
DATABASE Nucleotide 7 May 2020 (2020-05-07), "Homo sapiens killer cell lectin like receptor D1 (KLRD1), transcript variant 5, mRNA", XP055877738, retrieved from NCBI Database accession no. NM_001351062
DATABASE Nucleotide NCBI; 6 May 2020 (2020-05-06), "Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 1, mRNA ", XP055877725, retrieved from NCBI Database accession no. NM_001136068
DATABASE Nucleotide NCBI; 10 May 2020 (2020-05-10), "Homo sapiens killer cell lectin like receptor C1 (KLRC1), transcript variant 3, mRNA", XP055877718, retrieved from NCBI Database accession no. NM_213658
DATABASE Nucleotide 8 August 2019 (2019-08-08), "Mus musculus strain C57BL/6J chromosome 6, GRCm38.p6 C57BL/6J ", XP055877715, retrieved from NCBI Database accession no. NC_000072
DATABASE Nucleotide 2 March 2020 (2020-03-02), "Homo sapiens chromosome 12, GRCh38.p13 Primary Assembly", XP055877707, retrieved from NCBI Database accession no. NC_000012
ANDRÉ PASCALE; DENIS CAROLINE; SOULAS CAROLINE; BOURBON-CAILLET CLARISSE; LOPEZ JULIE; ARNOUX THOMAS; BLÉRY MATHIEU; BONNAFOUS CÉC: "Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells", CELL, ELSEVIER, AMSTERDAM NL, vol. 175, no. 7, 1 January 1900 (1900-01-01), Amsterdam NL , pages 1731, XP085560732, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.10.014
DATABASE Nucleotide 8 May 2020 (2020-05-08), "Mus musculus killer cell lectin-like receptor, subfamily D, member 1 (Klrd1), mRNA ", XP055877740, retrieved from NCBI Database accession no. NM_010654
DATABASE Nucleotide 7 May 2020 (2020-05-07), "Homo sapiens killer cell lectin like receptor D1 (KLRD1), transcript variant 5, mRNA", XP055877738, retrieved from NCBI Database accession no. NM_001351062
DATABASE Nucleotide NCBI; 6 May 2020 (2020-05-06), "Mus musculus killer cell lectin-like receptor subfamily C, member 1 (Klrc1), transcript variant 1, mRNA ", XP055877725, retrieved from NCBI Database accession no. NM_001136068
DATABASE Nucleotide NCBI; 10 May 2020 (2020-05-10), "Homo sapiens killer cell lectin like receptor C1 (KLRC1), transcript variant 3, mRNA", XP055877718, retrieved from NCBI Database accession no. NM_213658
DATABASE Nucleotide 8 August 2019 (2019-08-08), "Mus musculus strain C57BL/6J chromosome 6, GRCm38.p6 C57BL/6J ", XP055877715, retrieved from NCBI Database accession no. NC_000072
DATABASE Nucleotide 2 March 2020 (2020-03-02), "Homo sapiens chromosome 12, GRCh38.p13 Primary Assembly", XP055877707, retrieved from NCBI Database accession no. NC_000012
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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