Title:
GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC CD2
Document Type and Number:
WIPO Patent Application WO/2023/083250
Kind Code:
A1
Abstract:
Provided herein are genetically modified non-human animals that express a human or chimeric (e.g., humanized) CD2, and methods of use thereof.
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Inventors:
ZHAO YING (CN)
LI CHONG (CN)
SHEN ZHIYUAN (CN)
LI CHONG (CN)
SHEN ZHIYUAN (CN)
Application Number:
PCT/CN2022/131092
Publication Date:
May 19, 2023
Filing Date:
November 10, 2022
Export Citation:
Assignee:
BIOCYTOGEN PHARMACEUTICALS BEIJING CO LTD (CN)
International Classes:
A01K67/027; C07K14/705; C07K19/00; C12N5/16; C12N5/18; C12N15/12; C12N15/85; C12N15/90
Foreign References:
| US20190373869A1 | 2019-12-12 | |||
| CN107529739A | 2018-01-02 |
Other References:
LANG G., WOTTON D., OWEN M. J., SEWELL W. A., BROWN M. H., MASON D. Y., CRUMPTON M. J., KIOUSSIS D.: "The structure of the human CD2 gene and its expression in transgenic mice.", THE EMBO JOURNAL / EUROPEAN MOLECULAR BIOLOGY ORGANIZATION, IRL PRESS, OXFORD, vol. 7, no. 6, 1 June 1988 (1988-06-01), Oxford , pages 1675 - 1682, XP093065667, ISSN: 0261-4189, DOI: 10.1002/j.1460-2075.1988.tb02995.x
DATABASE Nucleotide NCBI; 26 October 2021 (2021-10-26), ANONYMOUS : "Mus musculus CD2 antigen (Cd2), mRNA ", XP093065670, Database accession no. NM_013486.2
DATABASE Nucleotide NCBI; 8 November 2021 (2021-11-08), ANONYMOUS : "Homo sapiens CD2 molecule (CD2), transcript variant 2, mRNA", XP093065672, Database accession no. NM_001767.5
DATABASE Nucleotide NCBI; 22 September 2020 (2020-09-22), ANONYMOUS : "Mus musculus strain C57BL/6J chromosome 3, GRCm39 ", XP093065674, Database accession no. NC_000069.7
DATABASE Nucleotide NCBI; 16 May 2021 (2021-05-16), ANONYMOUS : "Homo sapiens chromosome 1, GRCh38.p13 Primary Assembly ", XP093065682, Database accession no. NC_000001.11
DATABASE Nucleotide NCBI; 26 October 2021 (2021-10-26), ANONYMOUS : "Mus musculus CD2 antigen (Cd2), mRNA ", XP093065670, Database accession no. NM_013486.2
DATABASE Nucleotide NCBI; 8 November 2021 (2021-11-08), ANONYMOUS : "Homo sapiens CD2 molecule (CD2), transcript variant 2, mRNA", XP093065672, Database accession no. NM_001767.5
DATABASE Nucleotide NCBI; 22 September 2020 (2020-09-22), ANONYMOUS : "Mus musculus strain C57BL/6J chromosome 3, GRCm39 ", XP093065674, Database accession no. NC_000069.7
DATABASE Nucleotide NCBI; 16 May 2021 (2021-05-16), ANONYMOUS : "Homo sapiens chromosome 1, GRCh38.p13 Primary Assembly ", XP093065682, Database accession no. NC_000001.11
Attorney, Agent or Firm:
BEIJING LINKTEC IP LAW FIRM (SPECIAL GENERAL PARTNERSHIP) (CN)
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