Title:
GENOME EDITION USING CAS9 OR CAS9 VARIANT
Document Type and Number:
WIPO Patent Application WO/2021/215897
Kind Code:
A1
Abstract:
The present invention relates to a composition for editing a genome by using a Cas9 variant or a nucleic acid encoding same, a Cas9 or Cas9 variant or a nucleic acid encoding same, and to a method for editing a genome by using the composition. Specifically, the present invention relates to a composition for reducing unwanted insertions/deletions (indels) and editing a genome with excellent efficiency, by using a nuclease for prime editing or a variant thereof, for example, a Cas9 or a Cas9 variant, or a nucleic acid encoding same, and to a method for editing a genome using the composition.
Inventors:
KIM JIN-SOO (KR)
LIM KAYEONG (KR)
LEE JAESUK (KR)
LIM KAYEONG (KR)
LEE JAESUK (KR)
Application Number:
PCT/KR2021/005244
Publication Date:
October 28, 2021
Filing Date:
April 26, 2021
Export Citation:
Assignee:
INST BASIC SCIENCE (KR)
International Classes:
C12N15/10; C12N9/12; C12N9/22; C12N15/113
Foreign References:
| KR20180074610A | 2018-07-03 | |||
| KR20180084671A | 2018-07-25 | |||
| US20140335620A1 | 2014-11-13 | |||
| KR20180028028A | 2018-03-15 |
Other References:
ANZALONE ANDREW V.; RANDOLPH PEYTON B.; DAVIS JESSIE R.; SOUSA ALEXANDER A.; KOBLAN LUKE W.; LEVY JONATHAN M.; CHEN PETER J.; WILS: "Search-and-replace genome editing without double-strand breaks or donor DNA", NATURE, NATURE PUBLISHING GROUP UK, LONDON, vol. 576, no. 7785, 21 October 2019 (2019-10-21), London, pages 149 - 157, XP036953141, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1711-4
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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