Title:
GENOMIC FRAGMENT OF STREPTOCOCCUS SUIS AND CLINICAL USES THEREOF
Document Type and Number:
WIPO Patent Application WO2002038597
Kind Code:
A3
Abstract:
The invention relates to the field of diagnosis of and vaccination against Streptococcal infections and to the detection of virulence markers of Streptococci. The invention provides a method for modulating virulence of a Streptococcus comprising modifying a genomic fragment of said Streptococcus wherein said genomic fragment comprises at least a functional part of a fragment identifiable by hybridisation in Streptococcus suis to a nucleic acid or fragment thereof as shown in figure 5.
Inventors:
SMITH HILDA ELIZABETH (NL)
Application Number:
PCT/NL2001/000805
Publication Date:
August 08, 2002
Filing Date:
November 06, 2001
Export Citation:
Assignee:
ID LELYSTAD INST DIERHOUDERIJ (NL)
SMITH HILDA ELIZABETH (NL)
SMITH HILDA ELIZABETH (NL)
International Classes:
A61K38/16; C07K14/315; C07K16/12; C12N1/21; C12N15/31; A61K38/00; (IPC1-7): C12N15/31; C07K14/315; C07K16/12; A61K38/16
Domestic Patent References:
| WO2000005378A2 | 2000-02-03 |
Foreign References:
| US5610011A | 1997-03-11 |
Other References:
SMITH HILDE E ET AL: "Selection of virulence-associated determinants of Streptococcus suis serotype 2 by in vivo complementation.", INFECTION AND IMMUNITY, vol. 69, no. 3, March 2001 (2001-03-01), pages 1961 - 1966, XP002199921, ISSN: 0019-9567
SMITH H.E. ET AL: "Identification and characterization of the cps locus of Streptococcus suis serotype 2: The capsule protects against phagocytosis and is an important virulence factor.", INFECTION AND IMMUNITY, (1999) 67/4 (1750-1756)., XP002126886
SMITH, H. E. DE ET AL: "The cps locus of Streptococcus suis serotype 2: genetic determinant for the synthesis of sialic acid", MICROBIAL PATHOGENESIS, (2000) VOL. 29, NO. 2, PP. 127-134. 28 REF. ISSN: 0882-4010, Department of Bacteriology, Institute for Animal Science and Health, P.O. Box 65, 8200 AB Lelystad, Netherlands., XP000991174
BUSQUE P. ET AL: "Immunization of pigs against Streptococcus suis serotype 2 infection using a live avirulent strain.", CANADIAN JOURNAL OF VETERINARY RESEARCH, (1997) 61/4 (275-279)., XP000991156
SMITH H.E. ET AL: "Repeats in an extracellular protein of weakly pathogenic strains of Streptococcus suis type 2 are absent in pathogenic strains.", INFECTION AND IMMUNITY, (1993) 61/8 (3318-3326)., XP000990324
SMITH H.E. ET AL: "Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2.", INFECTION AND IMMUNITY, (1992) 60/6 (2361-2367)., XP000990323
ALLGAIER A. ET AL: "Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits.", JOURNAL OF CLINICAL MICROBIOLOGY, (2001) 39/2 (445-453)., XP000992120
SMITH H.E. ET AL: "Identification and characterization of the cps locus of Streptococcus suis serotype 2: The capsule protects against phagocytosis and is an important virulence factor.", INFECTION AND IMMUNITY, (1999) 67/4 (1750-1756)., XP002126886
SMITH, H. E. DE ET AL: "The cps locus of Streptococcus suis serotype 2: genetic determinant for the synthesis of sialic acid", MICROBIAL PATHOGENESIS, (2000) VOL. 29, NO. 2, PP. 127-134. 28 REF. ISSN: 0882-4010, Department of Bacteriology, Institute for Animal Science and Health, P.O. Box 65, 8200 AB Lelystad, Netherlands., XP000991174
BUSQUE P. ET AL: "Immunization of pigs against Streptococcus suis serotype 2 infection using a live avirulent strain.", CANADIAN JOURNAL OF VETERINARY RESEARCH, (1997) 61/4 (275-279)., XP000991156
SMITH H.E. ET AL: "Repeats in an extracellular protein of weakly pathogenic strains of Streptococcus suis type 2 are absent in pathogenic strains.", INFECTION AND IMMUNITY, (1993) 61/8 (3318-3326)., XP000990324
SMITH H.E. ET AL: "Cloning and nucleotide sequence of the gene encoding the 136-kilodalton surface protein (muramidase-released protein) of Streptococcus suis type 2.", INFECTION AND IMMUNITY, (1992) 60/6 (2361-2367)., XP000990323
ALLGAIER A. ET AL: "Relatedness of Streptococcus suis isolates of various serotypes and clinical backgrounds as evaluated by macrorestriction analysis and expression of potential virulence traits.", JOURNAL OF CLINICAL MICROBIOLOGY, (2001) 39/2 (445-453)., XP000992120
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