GEOMETRICALLY RESTRICTED 3-CYCLOPENTYLIDENE-1,3-DIHYDROINDOL-2-ONES AS POTENT PROTEIN KINASE INHIBITORS

Title:

GEOMETRICALLY RESTRICTED 3-CYCLOPENTYLIDENE-1,3-DIHYDROINDOL-2-ONES AS POTENT PROTEIN KINASE INHIBITORS

Document Type and Number:

WIPO Patent Application WO2005016875

Kind Code:

A3

Abstract:

The present invention relates to certain sulfonamido-substituted geometrically restricted indolinones of the formula (I): wherein R1 - R12 and X are variables defined herein. The sulfonamido-substituted geometrically restricted indolinones of the preferred embodiments of the present invention modulate the activity of protein kinases ("PKs"). The compounds of this invention are therefore useful in treating disorders related to abnormal PK activity. Pharmaceutical compositions comprising these compounds, methods of treating diseases utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.

Inventors:

ZHANG FANG-JIE (US)
CUI JINGRONG (US)
WEI CHUNG CHEN (US)
TANG PENG CHO (US)

Application Number:

PCT/US2004/022310

Publication Date:

July 28, 2005

Filing Date:

August 05, 2004

Export Citation:

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Assignee:

SUGEN INC (US)
ZHANG FANG-JIE (US)
CUI JINGRONG (US)
WEI CHUNG CHEN (US)
TANG PENG CHO (US)

International Classes:

A61K31/404; A61K31/4745; C07D209/34; C07D209/42; C07D403/04; C07D403/06; C07D403/14; C07D471/02; C07D471/04; C07D; (IPC1-7): A61K31/404; C07D403/04

Foreign References:

US6525072B1

2003-02-25

Other References: