Title:
GLOMERULAR SLIT PROTEIN INDUCER
Document Type and Number:
WIPO Patent Application WO/2007/125723
Kind Code:
A1
Abstract:
Disclosed is an agent for inducing or maintaining a glomerular slit protein, which comprises, as an active ingredient, the following component (1) or (2): (1) (i) an HGF protein or (ii) a peptide which is a partial peptide of the HGF protein and which has substantially the same activities as those of the HGF protein, or a salt thereof; or (2) DNA comprising (i) DNA encoding the HGF protein, (ii) DNA encoding a peptide which is a partial peptide of the HGF protein and which has substantially the same activities as those of the HGF protein, or (iii) DNA which can hybridize with DNA having a nucleotide sequence complementary to that of the DNA (i) or (ii) under stringent conditions and which encodes a protein or peptide having substantially the same activities as those of the HGF protein.
Inventors:
NAKAMURA TOSHIKAZU (JP)
MIZUNO SHINYA (JP)
IWATANI KUNIO (JP)
MIZUNO SHINYA (JP)
IWATANI KUNIO (JP)
Application Number:
PCT/JP2007/057121
Publication Date:
November 08, 2007
Filing Date:
March 30, 2007
Export Citation:
Assignee:
UNIV OSAKA (JP)
KRINGLE PHARMA INC (JP)
NAKAMURA TOSHIKAZU (JP)
MIZUNO SHINYA (JP)
IWATANI KUNIO (JP)
KRINGLE PHARMA INC (JP)
NAKAMURA TOSHIKAZU (JP)
MIZUNO SHINYA (JP)
IWATANI KUNIO (JP)
International Classes:
A61K38/00; A61K35/76; A61K48/00; A61P13/12
Other References:
ISOBE M.: "In vivo Electrophoration-ho o Mochiita Hepatocyte Growth Factor ni yoru Alport Shokogun Model Mouse no Idenshi Chiryo no Kento", NIIGATA MEDICAL JOURNAL, vol. 119, no. 10, 2005, pages 611 - 625, XP003018951
MIZUNO S. ET AL.: "Jinkino Chosetsu ni Okeru Hormone Oyobi Peptide no Bunshi Seibutsugaku - Seigosei, Taisha, Sayo - HGF ni yoru Jinsen'ika Kaijo to Sono Bunshi Kiko", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 64, no. 2, 28 February 2006 (2006-02-28), pages 312 - 321, XP003018952
MIZUNO S. ET AL.: "Jinshikkan Yobo Chiryoyaku to shiteno HGF", IGAKU NO AYUMI, vol. 209, no. 2, 2004, pages 124 - 126, XP003018953
ISONO M. ET AL.: "Tonyobyo no Idenshi Chiryo no Kiso Chishiki Tonyobyosei Jinsho no Idenshi Chiryo", DIABETES FRONTIER, vol. 15, no. 4, 2004, pages 515 - 519, XP003018954
KOBAYASHI N.: "Shikyutai Kino to Ashi Saibo (podocyte)", IGAKU NO AYUMI, 2003, pages 49 - 52, XP003018955
HAMANO Y. ET AL.: "Determinants of Vascular Permeability in the Kidney Glomerulus", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 34, 2002, pages 31154 - 31162, XP003018956
MIZUNO S. ET AL.: "Jinkino Chosetsu ni Okeru Hormone Oyobi Peptide no Bunshi Seibutsugaku - Seigosei, Taisha, Sayo - HGF ni yoru Jinsen'ika Kaijo to Sono Bunshi Kiko", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 64, no. 2, 28 February 2006 (2006-02-28), pages 312 - 321, XP003018952
MIZUNO S. ET AL.: "Jinshikkan Yobo Chiryoyaku to shiteno HGF", IGAKU NO AYUMI, vol. 209, no. 2, 2004, pages 124 - 126, XP003018953
ISONO M. ET AL.: "Tonyobyo no Idenshi Chiryo no Kiso Chishiki Tonyobyosei Jinsho no Idenshi Chiryo", DIABETES FRONTIER, vol. 15, no. 4, 2004, pages 515 - 519, XP003018954
KOBAYASHI N.: "Shikyutai Kino to Ashi Saibo (podocyte)", IGAKU NO AYUMI, 2003, pages 49 - 52, XP003018955
HAMANO Y. ET AL.: "Determinants of Vascular Permeability in the Kidney Glomerulus", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 34, 2002, pages 31154 - 31162, XP003018956
Attorney, Agent or Firm:
IWATANI, Ryo (1-31 Dojima 2-chome,Kita-ku, Osaka-sh, Osaka 03, JP)
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