Title:
GLP-1 RECEPTOR AGONIST COMPOUNDS HAVING STABILIZED REGIONS
Document Type and Number:
WIPO Patent Application WO/2012/015975
Kind Code:
A3
Abstract:
The disclosure provides GLP-1 receptor agonist compounds having stabilized regions corresponding to alpha-helical regions of the natural peptide compounds. The disclosure also provides benzamide-containing exendin-4 analogs and alkene-constrained exendin-4 analogs, both of which have stabilized regions corresponding to alpha-helical regions of exendin-4.
Inventors:
ALFARO-LOPEZ JOSUE (US)
SHARMA ABHINANDINI (US)
SOARES CHRISTOPHER J (US)
COATS EUGENE (US)
GHOSH SOUMITRA S (US)
SHARMA ABHINANDINI (US)
SOARES CHRISTOPHER J (US)
COATS EUGENE (US)
GHOSH SOUMITRA S (US)
Application Number:
PCT/US2011/045614
Publication Date:
May 10, 2012
Filing Date:
July 27, 2011
Export Citation:
Assignee:
AMYLIN PHARMACEUTICALS INC (US)
ALFARO-LOPEZ JOSUE (US)
SHARMA ABHINANDINI (US)
SOARES CHRISTOPHER J (US)
COATS EUGENE (US)
GHOSH SOUMITRA S (US)
ALFARO-LOPEZ JOSUE (US)
SHARMA ABHINANDINI (US)
SOARES CHRISTOPHER J (US)
COATS EUGENE (US)
GHOSH SOUMITRA S (US)
International Classes:
A61K38/26
Domestic Patent References:
| WO2010043047A1 | 2010-04-22 | |||
| WO2008112941A1 | 2008-09-18 |
Foreign References:
| US20070238669A1 | 2007-10-11 | |||
| US6620910B1 | 2003-09-16 | |||
| US20060183677A1 | 2006-08-17 |
Other References:
PLANTE ET AL.: "Oligobenzamide proteomimetic inhibitors of the p53-hDM2 protein-protein interaction.", CHEM. COMMUN., no. 34, 2009, pages 5091 - 5093, XP055091982
See also references of EP 2598161A4
See also references of EP 2598161A4
Attorney, Agent or Firm:
GRIEFF, Edward, D. (Inc.c/o Intellectual Property Group,9360 Towne Centre Driv, San Diego CA, US)
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