Title:
GLP-1/GCG/GIP TRIPLE-RECEPTOR AGONIST AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/067662
Kind Code:
A1
Abstract:
A triple-receptor agonist. The agonist comprises a polypeptide represented by formula (I), X 1X 2X 3GTX 6TSDYSIX 13X 14DX 16X 17X 18X 19X 20X 21FX 23X 24X 25LX 27X 28GGPSSGAPPPS (I), wherein X 1 is Y or H; X 2 is Aib; X 3 is Q or H; X 6 is an unnatural amino acid; X 13 is L or Y; X 14 is L or K; X 16 is E, K, or R; X 17 is K, R, or I; X 18 is A, R, or K; X 19 is Q or A; X 20 is R, K, Q, H, or Aib; X 21 is D, A, or E; X 23 is I or V; X 24 is E or Q; X 25 is W or Y; X 27 is I or L; and X 28 is E or A. The agonist has relatively strong agonistic activity on the three receptors GLP-1, GCG, and GIP and can be used for treating diseases related to metabolic disorders.
Inventors:
JIANG PENG (CN)
GUO LINFENG (CN)
ZHOU LINJUN (CN)
SUN NINGYUAN (CN)
XIAO LIN (CN)
YU JIANGHONG (CN)
CHEN JUNYING (CN)
LI LIJIA (CN)
LI YONG (CN)
LI MING (CN)
LI XIAOPING (CN)
LI JING (CN)
LI WENJIA (CN)
GUO LINFENG (CN)
ZHOU LINJUN (CN)
SUN NINGYUAN (CN)
XIAO LIN (CN)
YU JIANGHONG (CN)
CHEN JUNYING (CN)
LI LIJIA (CN)
LI YONG (CN)
LI MING (CN)
LI XIAOPING (CN)
LI JING (CN)
LI WENJIA (CN)
Application Number:
PCT/CN2023/121877
Publication Date:
April 04, 2024
Filing Date:
September 27, 2023
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07K14/605; A61K38/26; A61P3/00
Domestic Patent References:
| WO2022268029A1 | 2022-12-29 |
Foreign References:
| CN111511387A | 2020-08-07 | |||
| CN111491658A | 2020-08-04 | |||
| CN105829339A | 2016-08-03 | |||
| CN110023329A | 2019-07-16 | |||
| CN114437181A | 2022-05-06 |
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