Title:
GLUCOPYRANOSYL DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/149178
Kind Code:
A1
Abstract:
The present invention relates to a glucopyranosyl derivative and a use thereof. In particular, the present invention relates to a glucopyranosyl derivative that is used as an inhibitor of sodium-dependent glucose transporters (SGLTs), particularly being used as an inhibitor of sodium-dependent glucose transporter-1 (SGLT1), and a pharmaceutically acceptable salt or stereoisomer thereof, further relating to a pharmaceutical composition containing the derivative. The present invention further relates to a use of the compound and a pharmaceutical composition thereof in the preparation of a drug for treating diabetes and diabetes-related diseases.
Inventors:
GU ZHENG (CN)
WU WUYONG (CN)
KANG PANPAN (CN)
QU TONG (CN)
ZHANG ZONGYUAN (CN)
HUANG WEIMING (CN)
WU TIANYUN (CN)
ZHANG YINGJUN (CN)
WU WUYONG (CN)
KANG PANPAN (CN)
QU TONG (CN)
ZHANG ZONGYUAN (CN)
HUANG WEIMING (CN)
WU TIANYUN (CN)
ZHANG YINGJUN (CN)
Application Number:
PCT/CN2019/073550
Publication Date:
August 08, 2019
Filing Date:
January 29, 2019
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
C07H9/04; A61K31/7048; A61P3/10; A61P5/50; A61P9/10; A61P27/02; C07D493/08
Domestic Patent References:
WO2013038429A2 | 2013-03-21 | |||
WO2006035967A1 | 2006-04-06 |
Foreign References:
CN105461762A | 2016-04-06 | |||
CN104854096A | 2015-08-19 | |||
CN104619713B | 2017-06-16 | |||
US20110218159A1 | 2011-09-08 |
Other References:
MORIYA, R. ET AL., AM J PHYSIOL ENDORINOL METAB, vol. 297, 2009, pages E1358 - E1365
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SMITH ET AL.: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
T. W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
P. J. KOCIENSKI: "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, pages: 1289 - 1329
HIGUCHI ET AL.: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
ROCHE ET AL.: "Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", J. MED. CHEM., vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
BERGE ET AL., J. PHARMACOL SCI, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
ROBERT E. GAWLEYJEFFREY AUBE: "Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
S. P. PARKER: "McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
JOHANNSSON ET AL., J. CLIN. ENDOCRINOL. METAB., vol. 82, 1997, pages 727 - 734
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SMITH ET AL.: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
T. W. GREENE: "Protective Groups in Organic Synthesis", 1991, JOHN WILEY & SONS
P. J. KOCIENSKI: "Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS & WILKINS
"Remington's Pharmaceutical Sciences", 1985, MACK PUBLISHING COMPANY, pages: 1289 - 1329
HIGUCHI ET AL.: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
ROCHE ET AL.: "Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEWS DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", J. MED. CHEM., vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
BERGE ET AL., J. PHARMACOL SCI, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
ROBERT E. GAWLEYJEFFREY AUBE: "Principles of Asymmetric Synthesis", 2012, ELSEVIER
ELIEL, E.L.: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN, S.H.: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
S. P. PARKER: "McGraw-Hill Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
JOHANNSSON ET AL., J. CLIN. ENDOCRINOL. METAB., vol. 82, 1997, pages 727 - 734
STAHLWERMUTH: "Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
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