Title:
GLUCOSE-RESPONSIVE INSULIN CONJUGATES COMPRISING A TETRA-VALENT SUGAR CLUSTER FOR TREATMENT OF DIABETES
Document Type and Number:
WIPO Patent Application WO/2023/091441
Kind Code:
A8
Abstract:
An insulin conjugate comprising or consisting of a tetra-valent sugar cluster is described. The tetra-valent sugar cluster is provided by tetra-dentate linker having four arms, wherein each arm of the tetra-dentate linker is independently covalently linked to a ligand comprising or consisiting of a saccharide, such as a monosaccharide, disaccharide, trisaccharide, tetrasaccharide, or branched trisaccharide. In particular aspects, the insulin conjugate displays a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose.
Inventors:
HUO PEI (US)
LIN SONGNIAN (US)
MOYES CHRISTOPHER (US)
PISSARNITSKI DMITRI (US)
ZHAO ZHIQIANG (US)
HUNTER DAVID (US)
ZHU YUPING (US)
LIN SONGNIAN (US)
MOYES CHRISTOPHER (US)
PISSARNITSKI DMITRI (US)
ZHAO ZHIQIANG (US)
HUNTER DAVID (US)
ZHU YUPING (US)
Application Number:
PCT/US2022/050031
Publication Date:
July 20, 2023
Filing Date:
November 16, 2022
Export Citation:
Assignee:
MERCK SHARP & DOHME LLC (US)
International Classes:
A61K47/61; A61K38/28; A61K47/54; A61P3/10; C07K14/62
Attorney, Agent or Firm:
LAKE, Julie M. (US)
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