Title:
GLUCOSE-SENSITIVE CELL PROTECTING AGENT
Document Type and Number:
WIPO Patent Application WO/2016/159335
Kind Code:
A1
Abstract:
Provided is a means for reducing adverse effects of a high glucose concentration on the living body. Provided are: a preparation for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration, the preparation containing N-acetyl-D-mannosamine; a pharmaceutical composition for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration, the pharmaceutical composition containing an effective amount of N-acetyl-D-mannosamine and a pharmaceutically acceptable carrier; a use of N-acetyl-D-mannosamine to prepare a drug for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration; and a method for protecting glucose-sensitive cells from glucose toxicity caused by a high glucose concentration, the method including a step for administering an effective amount of N-acetyl-D-mannosamine to a subject in need thereof. The glucose-sensitive cells are selected from the group consisting of nerve cells, renal cells, and vascular endothelial cells.
Inventors:
SHIOTA KUNIO (JP)
HAYAKAWA KOJI (JP)
TAKAMORI MITSUKO (JP)
FUJII RYOSUKE (JP)
ITO YUKISHIGE (JP)
HAYAKAWA KOJI (JP)
TAKAMORI MITSUKO (JP)
FUJII RYOSUKE (JP)
ITO YUKISHIGE (JP)
Application Number:
PCT/JP2016/060882
Publication Date:
October 06, 2016
Filing Date:
April 01, 2016
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
A61K31/7008; A61P3/10; A61P25/00; A61P43/00
Foreign References:
| JP2013533857A | 2013-08-29 | |||
| JP2014024772A | 2014-02-06 |
Other References:
HAYAKAWA K. ET AL.: "Glucose causes neurodegeneration in induced orexin neurons.", MOLECULAR BIOLOGY OF THE CELL, vol. 25, no. 25, 15 December 2014 (2014-12-15), XP055317795
See also references of EP 3278806A4
See also references of EP 3278806A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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