Title:
α-GLUCOSIDASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2008/065796
Kind Code:
A1
Abstract:
It is intended to provide an α-glucosidase inhibitor which is new and has a high activity. Accordingly, after a root or/and aerial part of Salacia reticulata is extracted with water, insoluble components are removed by adding ethanol. Then, separation by fractionation was carried out using a synthetic adsorbent HP-20 (manufactured by Mitsubishi Chemical Corporation) column, an amino column or an ODS column, whereby a compound represented by the chemical formula (Kagaku 1) is obtained. This compound has an excellent α-glucosidase inhibitory activity, and is provided as a new anti-diabetic agent, or a health food capable of exhibiting a sugar absorption inhibitory effect.
Inventors:
OZAKI SEI (JP)
OE HIROMI (JP)
KITAMURA SHINICHI (JP)
OE HIROMI (JP)
KITAMURA SHINICHI (JP)
Application Number:
PCT/JP2007/067919
Publication Date:
June 05, 2008
Filing Date:
September 14, 2007
Export Citation:
Assignee:
FUJI SANGYO CO LTD (JP)
UNIV OSAKA PREFECTURE (JP)
OZAKI SEI (JP)
OE HIROMI (JP)
KITAMURA SHINICHI (JP)
UNIV OSAKA PREFECTURE (JP)
OZAKI SEI (JP)
OE HIROMI (JP)
KITAMURA SHINICHI (JP)
International Classes:
C07D337/00; A23L1/30; A61K31/38; A61P3/10; A61P43/00
Domestic Patent References:
| WO2004094402A1 | 2004-11-04 |
Other References:
YOSHIKAWA M. ET AL.: "Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats", JOURNAL OF NUTRITION, vol. 132, no. 7, 2002, pages 1819 - 1824, XP002997711
DATABASE CAPLUS [online] YOSHIKAWA M. ET AL.: "Absolute Stereostructure of Potent alpha-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata", XP003022683, accession no. STN Database accession no. (2005:1013398)
DATABASE CAPLUS [online] YOSHIKAWA M. ET AL.: "Absolute Stereostructure of Potent alpha-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata", XP003022683, accession no. STN Database accession no. (2005:1013398)
Attorney, Agent or Firm:
SHIMURA, Hisashi (2-3-4Minamisenba, Chuo-ku,Osaka-sh, Osaka 81, JP)
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