GLUCOSYLCERAMIDE SYNTHASE INHIBITORS AND THERAPEUTIC METHODS USING THE SAME

WIPO Patent Application WO/2016/126572

A3

Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

LARSEN SCOTT D (US)
ABE AKIRA (US)
SHU LIMING (US)
WILSON MICHAEL WILLIAM (US)
KEEP RICHARD F (US)
SUN DUXIN (US)
SHAYMAN JAMES A (US)

PCT/US2016/015883

November 03, 2016

February 01, 2016

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UNIV MICHIGAN REGENTS (US)

A61K31/401; C07D207/04; A61K31/421; A61P25/00; A61P25/28; C07D263/20

US20130095089A1	2013-04-18
US6855830B2	2005-02-15

BUCKLEY, BENJAMIN R. ET AL.: "A Rapid and Highly Diastereoselective Synthesis of Enant i omerically Pure (4R,5R)- and (4S,5S)-Isocytoxazone\", SYNLETT, 2011, pages 1399 - 1402, XP055326205
MITCHELL, SCOTT A. ET AL.: "Glycosyltransferase inhibitors: Synthesis of D-threo-PDMP, L-threo- PDMP, and other brain glucosylceramide synthase inhibitors from D- or L- Serine", JOURNAL OF ORGANIC CHEMISTRY, vol. 63, 1998, pages 8837 - 8842, XP002216878
SLAVISH, JACOB P. ET AL.: "New PDMP analogues inhibit process outgrowth in an insect cell line", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, 2004, pages 1487 - 1490, XP055153523

NAPOLI, James, J. (Gerstein & Borun LLP233 S. Wacker Drive,6300 Willis Towe, Chicago IL, US)

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