Title:
GLUCURONYLTRANSFERASE, GENE ENCODING SAME AND METHOD FOR USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/075572
Kind Code:
A1
Abstract:
The purpose of the present invention is to identify a gene of a first glucuronyltransferase that catalyzes the transfer of glucuronic acid to the hydroxyl group at the 3-position of an oleanane-type triterpenoid. Provided are first glucuronyltransferases having the target activity that are derived from plants of the leguminous family (soy beans, Glycyrrhiza uralensis and Lotus japonicus) and comprise respectively the base sequences represented by SEQ ID NOs: 2, 4 and 6.
Inventors:
MURANAKA TOSHIYA (JP)
SEKI HIKARU (JP)
CHUNG SOO YEON (JP)
ISHIMOTO MASAO (JP)
HIRAGA SUSUMU (JP)
SATOU YUKIKO (JP)
SEKI HIKARU (JP)
CHUNG SOO YEON (JP)
ISHIMOTO MASAO (JP)
HIRAGA SUSUMU (JP)
SATOU YUKIKO (JP)
Application Number:
PCT/JP2020/039175
Publication Date:
April 22, 2021
Filing Date:
October 16, 2020
Export Citation:
Assignee:
UNIV OSAKA (JP)
NAT AGRICULTURE & FOOD RES ORG (JP)
NAT AGRICULTURE & FOOD RES ORG (JP)
International Classes:
A01H1/00; A01H5/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/10; C12N15/54; C12N15/63; C12P19/56
Domestic Patent References:
| WO2009020231A1 | 2009-02-12 | |||
| WO2010024437A1 | 2010-03-04 | |||
| WO2014163174A1 | 2014-10-09 | |||
| WO2020049572A1 | 2020-03-12 | |||
| WO2019090181A1 | 2019-05-09 |
Foreign References:
| US20040031072A1 | 2004-02-12 | |||
| JPS5526323B2 | 1980-07-12 | |||
| JP5771846B2 | 2015-09-02 | |||
| JPS6344774B2 | 1988-09-06 | |||
| JP2019190060A | 2019-10-31 |
Other References:
DATABASE UNIPROT KB [online] 8 May 2019 (2019-05-08), "SubName: Full=Cellulose synthase-like protein G1", retrieved from Uniprot Database accession no. A0A445KH18
JOZWIAK, A. ET AL.: "Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery", NATURE CHEMICAL BIOLOGY, vol. 16, July 2020 (2020-07-01), pages 740 - 748, XP037175980, DOI: 10.1038/s41589-020-0541-x
CHUNG SOO YEON, SEKI HIKARU, FUJISAWA YUKIKO, SHIMODA YOSHIKAZU, HIRAGA SUSUMU, NOMURA YUHTA, SAITO KAZUKI, ISHIMOTO MASAO, MURANA: "A cellulose synthase-derived enzyme catalyses 3-0- glucuronosylation in saponin biosynthesis", NATURE COMMUNICATIONS, vol. 11, no. 5664, 16 November 2020 (2020-11-16), pages 1 - 11, XP055818986
GIBSON, M. R., LLOYDIA-THE JOURNAL OF NATURAL PRODUCTS, vol. 41, no. 4, 1978, pages 348 - 354
GREENSAMBROOK: "Molecular Cloning", 2012, COLD SPRING HARBOR LABORATORY PRESS
STRASSER R, GLYCOBIOLOGY, vol. 26, no. 9, 2016, pages 926 - 939
HAYASHI ET AL., PHYTOCHEMISTRY, vol. 42, 1996, pages 665 - 666
NOGUCHI ET AL., J. BIOL. CHEM., vol. 282, 2007, pages 23581 - 23590
DIAZ ET AL.: "Lotus japonicus Handbook", 2005, THE NETHERLANDS: SPRINGER, article "Induction of hairy roots for symbiotic gene expression studies", pages: 261 - 277
See also references of EP 4046479A4
JOZWIAK, A. ET AL.: "Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery", NATURE CHEMICAL BIOLOGY, vol. 16, July 2020 (2020-07-01), pages 740 - 748, XP037175980, DOI: 10.1038/s41589-020-0541-x
CHUNG SOO YEON, SEKI HIKARU, FUJISAWA YUKIKO, SHIMODA YOSHIKAZU, HIRAGA SUSUMU, NOMURA YUHTA, SAITO KAZUKI, ISHIMOTO MASAO, MURANA: "A cellulose synthase-derived enzyme catalyses 3-0- glucuronosylation in saponin biosynthesis", NATURE COMMUNICATIONS, vol. 11, no. 5664, 16 November 2020 (2020-11-16), pages 1 - 11, XP055818986
GIBSON, M. R., LLOYDIA-THE JOURNAL OF NATURAL PRODUCTS, vol. 41, no. 4, 1978, pages 348 - 354
GREENSAMBROOK: "Molecular Cloning", 2012, COLD SPRING HARBOR LABORATORY PRESS
STRASSER R, GLYCOBIOLOGY, vol. 26, no. 9, 2016, pages 926 - 939
HAYASHI ET AL., PHYTOCHEMISTRY, vol. 42, 1996, pages 665 - 666
NOGUCHI ET AL., J. BIOL. CHEM., vol. 282, 2007, pages 23581 - 23590
DIAZ ET AL.: "Lotus japonicus Handbook", 2005, THE NETHERLANDS: SPRINGER, article "Induction of hairy roots for symbiotic gene expression studies", pages: 261 - 277
See also references of EP 4046479A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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