Title:
GLUTAMATE RELEASE INHIBITOR AND NOVEL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/1998/018760
Kind Code:
A1
Abstract:
Compounds having a glutamate release inhibitory activity and not having the function of conventionally known sodium channel blockers and calcium channel blockers at all. The compounds are aromatic ketone derivatives represented by general formula (I), pharmacologically acceptable salts thereof, or hydrates of the salts.
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Inventors:
OSHIMA TAKEO (JP)
KAMIGAUCHI TOSHIYUKI (JP)
FUKUI YOSHIKAZU (JP)
KAMIGAUCHI TOSHIYUKI (JP)
FUKUI YOSHIKAZU (JP)
Application Number:
PCT/JP1997/003884
Publication Date:
May 07, 1998
Filing Date:
October 27, 1997
Export Citation:
Assignee:
SHIONOGI & CO (JP)
OSHIMA TAKEO (JP)
KAMIGAUCHI TOSHIYUKI (JP)
FUKUI YOSHIKAZU (JP)
OSHIMA TAKEO (JP)
KAMIGAUCHI TOSHIYUKI (JP)
FUKUI YOSHIKAZU (JP)
International Classes:
C07D207/333; C07D207/34; C07D213/50; C07D307/46; C07D333/22; C07D207/32; (IPC1-7): C07D207/333; A61K31/33; A61K31/34; A61K31/38; A61K31/40; A61K31/44; C07D207/34; C07D213/50; C07D307/46; C07D333/22
Foreign References:
| JPS56120668A | 1981-09-22 |
Other References:
J. PHARM. SCI., Vol. 62, No. 5, (1973), BREEN M.P. et al., "Anticonvulsant Activity of Substituted Benzoylpyridines", p. 847-849.
J. MED. CHEM., Vol. 11, (1968), MOFFETT ROBERT BRUCE, "Central Nervous System Depressants. VIII. Pyrroles", p. 1251-1252.
EUR. J. MED. CHEM.-CHIMICA THERAPEUTICA, Vol. 9, No. 4, (1974), CLEMENCE FRANCOIS et al., "Recherche de Composes Anti-Inflammatoires et Analgesiques Dans la Serie du Thiophene", p. 390-396.
J. MED. CHEM., Vol. 32, (1989), MUCHOWSKI JOSEPH M. et al., "Synthesis and Antiinflammatory and Analgesic Activity of 5-Aroyl-6-(Methylthio)-1,2-Dihydro-3H-Pyrro lo(1,2-a)Pyrrole-1-Carboxylic Acids and 1-Methyl-4-(Methyltho)-5-Aroylpyrrole-2-Ace tic Acids", p. 1202-1207.
J. PHARM. PHARMACOL., Vol. 47, (1995), LING-YIH HSU et al., "2-Heteroaryl 2-Substituted Phenylketone Derivatives and Their Inhibitory Activity on Platelet Aggregation", p. 762-767.
J. MED. CHEM., Vol. 12, No. 5, (1969), HARDMANN GOETZ et al., "Antiinflammatory Aryl Pyridyl Ketones", p. 1093-1096.
J. ANTIBIOT., Vol. 45, No. 6, (1992), CONDER GEORGE A. et al., "Anthemintic Activity of Dioxapyrrolomycin", p. 977-983.
J. MED. CHEM., Vol. 11, (1968), MOFFETT ROBERT BRUCE, "Central Nervous System Depressants. VIII. Pyrroles", p. 1251-1252.
EUR. J. MED. CHEM.-CHIMICA THERAPEUTICA, Vol. 9, No. 4, (1974), CLEMENCE FRANCOIS et al., "Recherche de Composes Anti-Inflammatoires et Analgesiques Dans la Serie du Thiophene", p. 390-396.
J. MED. CHEM., Vol. 32, (1989), MUCHOWSKI JOSEPH M. et al., "Synthesis and Antiinflammatory and Analgesic Activity of 5-Aroyl-6-(Methylthio)-1,2-Dihydro-3H-Pyrro lo(1,2-a)Pyrrole-1-Carboxylic Acids and 1-Methyl-4-(Methyltho)-5-Aroylpyrrole-2-Ace tic Acids", p. 1202-1207.
J. PHARM. PHARMACOL., Vol. 47, (1995), LING-YIH HSU et al., "2-Heteroaryl 2-Substituted Phenylketone Derivatives and Their Inhibitory Activity on Platelet Aggregation", p. 762-767.
J. MED. CHEM., Vol. 12, No. 5, (1969), HARDMANN GOETZ et al., "Antiinflammatory Aryl Pyridyl Ketones", p. 1093-1096.
J. ANTIBIOT., Vol. 45, No. 6, (1992), CONDER GEORGE A. et al., "Anthemintic Activity of Dioxapyrrolomycin", p. 977-983.
Attorney, Agent or Firm:
Yamauchi, Hideaki (Sagisu 5-chome Fukushima-k, Osaka-shi Osaka, JP)
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