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Title:
GLYCATED HEMOGLOBIN OXIDASE VARIANT AND MEASUREMENT METHOD
Document Type and Number:
WIPO Patent Application WO/2019/045052
Kind Code:
A1
Abstract:
To provide a glycated hemoglobin oxidase that, even with samples containing a glycated abnormal hemoglobin, produces little measurement error or does not produce deviation between the measured value and the true value. Provided are: a glycated hemoglobin oxidase in which the amino acid at position 113, 109, 106, or 102 in the amino acid sequence of SEQ ID NO: 1 is replaced by an amino acid, for example, glutamic acid, alanine, or aspartic acid, other than a positively charged amino acid; and a method for measuring glycated hemoglobin and a measurement reagent kit that use this glycated hemoglobin oxidase. Glycated hemoglobin can be accurately measured for various genotypes even for samples containing glycated abnormal hemoglobin.

Inventors:
ICHIYANAGI ATSUSHI (JP)
Application Number:
PCT/JP2018/032389
Publication Date:
March 07, 2019
Filing Date:
August 31, 2018
Export Citation:
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Assignee:
KIKKOMAN CORP (JP)
International Classes:
C12N15/53; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/04; C12P21/02; C12Q1/00; C07K14/805
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Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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