GLYCEROL DERIVATIVE, DEVICE AND PHARMACEUTICAL COMPOSITION

WIPO Patent Application WO/1994/019314

A1

The invention aims at providing a device comprising lipids that act like the so-called cationic liposome and are reduced in toxicity and the lipids as the constituent of the device. The invention compounds are exemplified by 3-0-(4-dimethylaminobutanoyl)-1,2-0-dioleylglycerol, 3-0-(2-dimethylaminoethyl)carbamoyl-1,2-0-dioleylglycerol, 3-0-(2-diethylaminoethyl)carbamoyl-1,2-0-dioleylglycerol, and 2-0-(2-diethylaminoethyl)-carbamoyl-1,3-0-dioleylglycerol. The device comprises these lipids and phospholipids. The device enables, when administered together with, for example, a double-stranded RNA, the RNA to migrate to the action site safely.

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YANO JUNICHI (JP)
OHGI TADAAKI (JP)

PCT/JP1994/000237

September 01, 1994

February 17, 1994

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NIPPON SHINYAKU CO LTD (JP)
YANO JUNICHI (JP)
OHGI TADAAKI (JP)

A61K31/70; A61K9/127; A61K9/52; A61K9/66; A61K47/10; A61K47/24; A61K47/44; C07C229/06; C07C229/12; C07C237/08; C07C271/16; C07C271/20; C07C279/04; C07C279/20; C07C307/02; C07C333/04; C07D207/08; C07D211/08; C07D241/04; C07D265/30; C07D295/13; C07F9/40; (IPC1-7): C07C229/06; C07C237/08; C07C271/16; C07C279/04; C07C307/02; C07D207/08; C07D211/08; C07D241/04; C07D265/30; C07F9/40

WO1985002118A1

1985-05-23

EP0451763A2	1991-10-16
JPS60104066A	1985-06-08
US4851232A	1989-07-25
EP0313992A1	1989-05-03

See also references of EP 0685457A4

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