Title:
GLYCINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2006/068213
Kind Code:
A1
Abstract:
A glycine derivative which is, e.g., the following compound (Chemical formula (1)). It is highly effective in the treatment and prevention of inflammatory bowel diseases. Compared to conventional compounds, the compound is excellent in absorbability in oral administration and in vivo stability. The compound can be orally administered and can retain an excellent therapeutic or preventive effect over a longer period.
Inventors:
HIRANO NORIYUKI (JP)
INOUE HIDEKI (JP)
NAGAHARA TAKASHI (JP)
OHYAMA TOMOFUMI (JP)
KAINO MIE (JP)
HAYASHI KENICHI (JP)
HARA SUNAO (JP)
SUZUKI RYUTARO (JP)
INOUE HIDEKI (JP)
NAGAHARA TAKASHI (JP)
OHYAMA TOMOFUMI (JP)
KAINO MIE (JP)
HAYASHI KENICHI (JP)
HARA SUNAO (JP)
SUZUKI RYUTARO (JP)
Application Number:
PCT/JP2005/023577
Publication Date:
June 29, 2006
Filing Date:
December 22, 2005
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
HIRANO NORIYUKI (JP)
INOUE HIDEKI (JP)
NAGAHARA TAKASHI (JP)
OHYAMA TOMOFUMI (JP)
KAINO MIE (JP)
HAYASHI KENICHI (JP)
HARA SUNAO (JP)
SUZUKI RYUTARO (JP)
HIRANO NORIYUKI (JP)
INOUE HIDEKI (JP)
NAGAHARA TAKASHI (JP)
OHYAMA TOMOFUMI (JP)
KAINO MIE (JP)
HAYASHI KENICHI (JP)
HARA SUNAO (JP)
SUZUKI RYUTARO (JP)
International Classes:
C07D239/34; A61K31/335; A61K31/351; A61K31/505; A61K31/506; A61P1/00; A61P1/12; A61P29/00; C07D239/42; C07D239/46; C07D239/47; C07D239/52; C07D239/60; C07D309/10; C07D313/04; C07D401/12; C07D405/12; C07D417/12
Domestic Patent References:
| WO1999026923A1 | 1999-06-03 | |||
| WO1995032710A1 | 1995-12-07 | |||
| WO2003053926A1 | 2003-07-03 | |||
| WO2001070670A1 | 2001-09-27 | |||
| WO1999026923A1 | 1999-06-03 | |||
| WO1995032710A1 | 1995-12-07 |
Other References:
REV. GASTROENTEROL DISORD., vol. 4, 2004, pages 66
ARCH. PHARMACAL. RES., vol. 22, 1999, pages 354
TRENDS. PHARMACOL. SCI., vol. 25, 2004, pages 430
ANNU REV IMMUNOL., vol. 11, 1993, pages 767
GUT., vol. 36, 1995, pages 724
RES. IMMUNOL., vol. 144, 1993, pages 723
ADV. IMMUNOL., vol. 72, 1999, pages 325
AM. J. PHATHOL., vol. 151, 1997, pages 97
J. IMMUNOL., vol. 151, 1993, pages 2471
INFLAMMATORY BOWEL DISEASE, vol. 8, 2002, pages 291
J. CLIN. INVEST., vol. 92, 1993, pages 372
J. IMMUNOL., vol. 151, 1993, pages 4790
GASTROENTEROLOGY, vol. 111, 1996, pages 1373
LABORATORY INVESTIG., vol. 69, 1993, pages 238 - 249
IMMUNITY, vol. 1, 1994, pages 553 - 562
CELL, vol. 75, 1993, pages 203 - 205
J. GASTROENTEROL., vol. 37, 2002, pages 409 - 17
"Current Protocols in Immunology", JOHN WILEY & SONS, INC
DIG DIS SCI., vol. 38, 1993, pages 1722
ARCH. PHARMACAL. RES., vol. 22, 1999, pages 354
TRENDS. PHARMACOL. SCI., vol. 25, 2004, pages 430
ANNU REV IMMUNOL., vol. 11, 1993, pages 767
GUT., vol. 36, 1995, pages 724
RES. IMMUNOL., vol. 144, 1993, pages 723
ADV. IMMUNOL., vol. 72, 1999, pages 325
AM. J. PHATHOL., vol. 151, 1997, pages 97
J. IMMUNOL., vol. 151, 1993, pages 2471
INFLAMMATORY BOWEL DISEASE, vol. 8, 2002, pages 291
J. CLIN. INVEST., vol. 92, 1993, pages 372
J. IMMUNOL., vol. 151, 1993, pages 4790
GASTROENTEROLOGY, vol. 111, 1996, pages 1373
LABORATORY INVESTIG., vol. 69, 1993, pages 238 - 249
IMMUNITY, vol. 1, 1994, pages 553 - 562
CELL, vol. 75, 1993, pages 203 - 205
J. GASTROENTEROL., vol. 37, 2002, pages 409 - 17
"Current Protocols in Immunology", JOHN WILEY & SONS, INC
DIG DIS SCI., vol. 38, 1993, pages 1722
Attorney, Agent or Firm:
Iwami, Tomonori c/o Intellectual Property Department (Toray Industries Inc., 1-1, Sonoyama 1-chome, Otsu-sh, Shiga 58, JP)
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