GLYCINE N-METHYL TRANSFERASE (GNMT) MUTANT GENE AND APPLICATIONS THEREOF

WIPO Patent Application WO/2018/209639

A1

Provided a lycine N-methyl transferase (GNMT) mutant gene which can prevent micro RNA has-miR-244 interference related to cancers, and which then can be used for preventing or treating liver diseases, the GNMT mutant gene being selected from a sequence shown in one of the SEQ ID NOs:3-15. Also provided is recombinant vector that is formed by carrying the GNMT mutant gene in an adeno-associated virus vector, and pharmaceutical uses thereof.

JP2001511349	[Title of the Invention] Genes for biosynthesis and transfer of 6-deoxyhexose in Saccharopolysporaerythraea and Streptomyces antibioticus
JP6874994	How to attenuate the differentiation resistance of pluripotent stem cells
WO/2009/143446	LAMBDASA2 ENDOLYSIN TRUNCATION

CHEN YI-MING (CN)
HUNG JUNG-HSIEN (CN)
FANG CHENG-CHIEH (CN)

PCT/CN2017/084882

November 22, 2018

May 18, 2017

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UNIV KAOHSIUNG MEDICAL (CN)

C12N15/52; A61K48/00; A61P1/16; A61P35/00; C12N15/86

CN101407815A	2009-04-15
CN1627076A	2005-06-15
CN101874478A	2010-11-03
CN103060351A	2013-04-24

YE, KAN ET AL.: "Preliminary Research on the Interaction between GNMT and ARRB1", JOURNAL OF FUDAN UNIVERSITY, vol. 49, no. 1, 28 February 2010 (2010-02-28), pages 29 - 35, 42
FERNANDEZ-ALYAREZL, SARA ET AL.: "TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency", LABORATORY INVESTIGATION: A JOURNAL OF TECHNICAL METHODS AND PATHOLOGY, vol. 95, no. 2, 28 February 2015 (2015-02-28), pages 223 - 236, XP055612358, ISSN: 0023-6837

TEE&HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)

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