Title:
GLYCINE N-METHYLTRANSFERASE ENHANCER, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/134043
Kind Code:
A1
Abstract:
A nicotinic hydrazide derivative, a stereoisomer thereof, and a pharmaceutically acceptable salt thereof. The nicotinic hydrazide derivative has a molecular formula (I), wherein each of X, Y, and Z is one of N and CH, at least one of X, Y, and Z is CH, at least one of X, Y, and Z is N, and R is one of OH and NH2.
Inventors:
CHEN YI-MING (CN)
TZENG CHERNG-CHYI (CN)
CHEN YEH-LONG (CN)
TSENG CHIH-HUA (CN)
YEN CHIA-HUNG (CN)
KANT RAJNI (CN)
YANG MING-HUI (CN)
TZENG CHERNG-CHYI (CN)
CHEN YEH-LONG (CN)
TSENG CHIH-HUA (CN)
YEN CHIA-HUNG (CN)
KANT RAJNI (CN)
YANG MING-HUI (CN)
Application Number:
PCT/CN2020/139547
Publication Date:
June 30, 2022
Filing Date:
December 25, 2020
Export Citation:
Assignee:
UNIV KAOHSIUNG MEDICAL (CN)
International Classes:
C07D401/12; A61K31/444; A61P35/00; C07B43/00
Domestic Patent References:
| WO2018017589A1 | 2018-01-25 |
Foreign References:
| CN103880707A | 2014-06-25 |
Other References:
SINGH RAVINDRA KUMAR, SINGH ASHOK KUMAR, SIDDIQUI SAHABJADA, ARSHAD MOHAMMAD, JAFRI ASIF: "Synthesis, molecular structure, spectral analysis and cytotoxic activity of two new aroylhydrazones", JOURNAL OF MOLECULAR STRUCTURE, ELSEVIER AMSTERDAM, NL, vol. 1135, 1 May 2017 (2017-05-01), NL , pages 82 - 97, XP055945522, ISSN: 0022-2860, DOI: 10.1016/j.molstruc.2017.01.059
C. H. KANE, D. TINGUIANO, F. B. TAMBOURA, I. E. THIAM, A. H. BARRY, M. GAYE, P. RETAILLEAU: "Synthesis and characterization of novel M(II) (M = Mn(II), Ni(II), Cu(II) or Zn(II)) complexes with tridentate N2,O-donor ligand (E)-2-amino-N’-[1-(pyridin-2-yl)- ethylidene]benzohydrazide", BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, vol. 30, no. 1, pages 101, XP055643953, DOI: 10.4314/bcse.v30i1.9
GUPTA NISHA, BADEAUX MARK, LIU YIQIAN, NAXEROVA KAMILA, SGROI DENNIS, MUNN LANCE L., JAIN RAKESH K., GARKAVTSEV IGOR: "Stress granule-associated protein G3BP2 regulates breast tumor initiation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 114, no. 5, 31 January 2017 (2017-01-31), pages 1033 - 1038, XP055945526, ISSN: 0027-8424, DOI: 10.1073/pnas.1525387114
GUO-PING CHENG; LING-WEI XUE; WEI-CHUN YANG: "Synthesis, Characterization and Crystal Structures of 3-Hydroxy--[methyl(2-pyridyl)methylene]-2-naphthohydrazide monohydrate and 3-Hydroxy--(3,5-dibromo-2-hydroxybenzylidene)-2-naphthohydrazide dimethylformamide solvate", JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 42, no. 7, 28 February 2012 (2012-02-28), Ne , pages 668 - 672, XP035075228, ISSN: 1572-8854, DOI: 10.1007/s10870-012-0297-6
C. H. KANE, D. TINGUIANO, F. B. TAMBOURA, I. E. THIAM, A. H. BARRY, M. GAYE, P. RETAILLEAU: "Synthesis and characterization of novel M(II) (M = Mn(II), Ni(II), Cu(II) or Zn(II)) complexes with tridentate N2,O-donor ligand (E)-2-amino-N’-[1-(pyridin-2-yl)- ethylidene]benzohydrazide", BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, vol. 30, no. 1, pages 101, XP055643953, DOI: 10.4314/bcse.v30i1.9
GUPTA NISHA, BADEAUX MARK, LIU YIQIAN, NAXEROVA KAMILA, SGROI DENNIS, MUNN LANCE L., JAIN RAKESH K., GARKAVTSEV IGOR: "Stress granule-associated protein G3BP2 regulates breast tumor initiation", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 114, no. 5, 31 January 2017 (2017-01-31), pages 1033 - 1038, XP055945526, ISSN: 0027-8424, DOI: 10.1073/pnas.1525387114
GUO-PING CHENG; LING-WEI XUE; WEI-CHUN YANG: "Synthesis, Characterization and Crystal Structures of 3-Hydroxy--[methyl(2-pyridyl)methylene]-2-naphthohydrazide monohydrate and 3-Hydroxy--(3,5-dibromo-2-hydroxybenzylidene)-2-naphthohydrazide dimethylformamide solvate", JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, vol. 42, no. 7, 28 February 2012 (2012-02-28), Ne , pages 668 - 672, XP035075228, ISSN: 1572-8854, DOI: 10.1007/s10870-012-0297-6
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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