Title:
GLYCINE TRANSPORTER INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2010/107115
Kind Code:
A1
Abstract:
Provided is a novel compound or a pharmaceutically acceptable salt thereof, which is useful for preventing or treating diseases attributed to glycine uptake inhibitory activity such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (such as generalized anxiety disorders, panic disorders, obsessive-compulsive disorders, social anxiety disorders, post-traumatic stress disorders, specific phobia, and acute stress disorders), depression, drug dependence, convulsion, tremor, and sleep disorders. The compound is represented by formula [I].
Inventors:
YASUHARA AKITO (JP)
YAMAMOTO SHUJI (JP)
OHTA HIROSHI (JP)
SHIRASAKI YOSHIHISA (JP)
SAKAGAMI KAZUNARI (JP)
HAYASHI MASATO (JP)
SHIBATA TSUYOSHI (JP)
SHIMAZAKI YOUICHI (JP)
ARAKI YUKO (JP)
ABE KUMI (JP)
SUN XIANG-MIN (JP)
YAMAMOTO SHUJI (JP)
OHTA HIROSHI (JP)
SHIRASAKI YOSHIHISA (JP)
SAKAGAMI KAZUNARI (JP)
HAYASHI MASATO (JP)
SHIBATA TSUYOSHI (JP)
SHIMAZAKI YOUICHI (JP)
ARAKI YUKO (JP)
ABE KUMI (JP)
SUN XIANG-MIN (JP)
Application Number:
PCT/JP2010/054831
Publication Date:
September 23, 2010
Filing Date:
March 19, 2010
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
YASUHARA AKITO (JP)
YAMAMOTO SHUJI (JP)
OHTA HIROSHI (JP)
SHIRASAKI YOSHIHISA (JP)
SAKAGAMI KAZUNARI (JP)
HAYASHI MASATO (JP)
SHIBATA TSUYOSHI (JP)
SHIMAZAKI YOUICHI (JP)
ARAKI YUKO (JP)
ABE KUMI (JP)
SUN XIANG-MIN (JP)
YASUHARA AKITO (JP)
YAMAMOTO SHUJI (JP)
OHTA HIROSHI (JP)
SHIRASAKI YOSHIHISA (JP)
SAKAGAMI KAZUNARI (JP)
HAYASHI MASATO (JP)
SHIBATA TSUYOSHI (JP)
SHIMAZAKI YOUICHI (JP)
ARAKI YUKO (JP)
ABE KUMI (JP)
SUN XIANG-MIN (JP)
International Classes:
C07D405/12; A61K31/4178; A61K31/4196; A61K31/437; A61K31/4439; A61P25/08; A61P25/14; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D405/14; C07D409/12; C07D471/04
Domestic Patent References:
| WO2008065500A2 | 2008-06-05 | |||
| WO2005037216A2 | 2005-04-28 | |||
| WO2006106425A1 | 2006-10-12 | |||
| WO2008065500A2 | 2008-06-05 |
Foreign References:
| JP2007508374A | 2007-04-05 | |||
| JP2008534671A | 2008-08-28 | |||
| JP2008536829A | 2008-09-11 |
Other References:
MOLECULAR PSYCHIATRY, vol. 9, 2004, pages 984 - 997
CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 1017 - 1044
NEUROPSYCHOPHARMACOLOGY, 2005, pages 1 - 23
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 2, 2004, pages 201 - 214
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 2974 - 2976
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 907 - 911
PHARMACEUTICAL RESEARCH, vol. 19, no. 7, 2002, pages 921 - 925
J PHARMACOL. EXP. THER., vol. 263, no. 2, 1992, pages 840 - 845
J BIOL. CHEM., vol. 267, no. 34, 1992, pages 24248 - 24252
NATURE REVIEWS DRUG DISCOVERY, vol. 9, 2010, pages 215 - 236
PHARMACEUTICAL RESEARCH, vol. 18, no. 12, 2001, pages 1660 - 1668
See also references of EP 2409976A4
CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 1017 - 1044
NEUROPSYCHOPHARMACOLOGY, 2005, pages 1 - 23
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 2, 2004, pages 201 - 214
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 2974 - 2976
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 20, 2010, pages 907 - 911
PHARMACEUTICAL RESEARCH, vol. 19, no. 7, 2002, pages 921 - 925
J PHARMACOL. EXP. THER., vol. 263, no. 2, 1992, pages 840 - 845
J BIOL. CHEM., vol. 267, no. 34, 1992, pages 24248 - 24252
NATURE REVIEWS DRUG DISCOVERY, vol. 9, 2010, pages 215 - 236
PHARMACEUTICAL RESEARCH, vol. 18, no. 12, 2001, pages 1660 - 1668
See also references of EP 2409976A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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