Title:
GLYCINE TRANSPORTER INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2015/012400
Kind Code:
A1
Abstract:
The present invention provides a novel compound represented by the following formula (I), or a pharmaceutically acceptable salt thereof, which, on the basis of glycine reuptake inhibiting action, is useful in prevention or treatment of disorders such as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobias, acute stress disorder, and the like), depression, chemical dependence, tics, tremors, pain, Parkinson's disease, attention-deficit hyperactivity disorder, bipolar disorder, eating disorders, sleep disorders, and the like.
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Inventors:
WAKASUGI DAISUKE (JP)
OHTA HIROSHI (JP)
OKADA KUMIKO (JP)
SHIROKAWA SHIN-ICHI (JP)
MORIYA MINORU (JP)
TAMITA TOMOKO (JP)
ABE KUMI (JP)
HATTORI NOBUTAKA (JP)
ARAKI YUKO (JP)
OHTA HIROSHI (JP)
OKADA KUMIKO (JP)
SHIROKAWA SHIN-ICHI (JP)
MORIYA MINORU (JP)
TAMITA TOMOKO (JP)
ABE KUMI (JP)
HATTORI NOBUTAKA (JP)
ARAKI YUKO (JP)
Application Number:
PCT/JP2014/069747
Publication Date:
January 29, 2015
Filing Date:
July 25, 2014
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D209/34; A61K31/404; A61K31/416; A61K31/4184; A61K31/422; A61K31/423; A61K31/4245; A61K31/428; A61K31/4355; A61K31/437; A61K31/4375; A61K31/4439; A61K31/4709; A61K31/4725; A61K31/497; A61K31/498; A61K31/517; A61K31/519; A61K31/53; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P43/00; C07D401/06; C07D401/14; C07D403/06; C07D405/06; C07D405/14; C07D409/06; C07D413/06; C07D417/06; C07D471/04; C07D491/048
Domestic Patent References:
| WO2011012622A1 | 2011-02-03 | |||
| WO2011023753A1 | 2011-03-03 | |||
| WO2011092293A2 | 2011-08-04 | |||
| WO2011012622A1 | 2011-02-03 | |||
| WO2011023753A1 | 2011-03-03 |
Other References:
DOHI TOSHIHIRO ET AL.: "GLYCINE TRANSPORTER INHIBITORS AS A NOVEL DRUG DISCOVERY STRATEGY FOR NEUROPATHIC PAIN", PHARMACOLOGY & THERAPEUTICS, vol. 123, no. 1, July 2009 (2009-07-01), pages 54 - 79, XP026139479
LOWE III JOHN A: "NOVEL INHIBITORS OF THE TYPE 1 TRANSPORTER FOR GLYCINE (GLYT1) AS ANTIPSYCHOTIC AGENTS", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 15, no. 11, November 2005 (2005-11-01), pages 1657 - 1662, XP002372471
MOLECULAR PSYCHIATRY, vol. 9, 2004, pages 984 - 997
CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 1017 - 1044
NEUROPSYCHOPHARMACOLOGY, vol. 30, 2005, pages 1963 - 1985
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 2, 2004, pages 201 - 214
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis"
NEURON, vol. 8, 1992, pages 927 - 935
See also references of EP 3026043A4
LOWE III JOHN A: "NOVEL INHIBITORS OF THE TYPE 1 TRANSPORTER FOR GLYCINE (GLYT1) AS ANTIPSYCHOTIC AGENTS", EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 15, no. 11, November 2005 (2005-11-01), pages 1657 - 1662, XP002372471
MOLECULAR PSYCHIATRY, vol. 9, 2004, pages 984 - 997
CURRENT MEDICINAL CHEMISTRY, vol. 13, 2006, pages 1017 - 1044
NEUROPSYCHOPHARMACOLOGY, vol. 30, 2005, pages 1963 - 1985
EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 14, no. 2, 2004, pages 201 - 214
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis"
NEURON, vol. 8, 1992, pages 927 - 935
See also references of EP 3026043A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
Ono Shinjiro (JP)
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