Title:
GLYCOGEN PHOSPHORYLASE INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2013/061105
Kind Code:
A8
Abstract:
The invention relates to compounds of formula (I) and stereoisomers, tautomers and pharmaceutically acceptable salts thereof and processes for preparing them. In formula (I) X is -CH= or -N= or -N(R") -; Y is -N= or -N(R") -; R is an alkyl group, an aryl group or a heteroaryl group, which groups are unsubstituted or substituted; R' is hydrogen or PG1, R" is hydrogen or PG2, R"' is hydrogen or R'OCH2-; n is an integer of 1 to 3. The invention also relates to pharmaceutical compositions containing these compounds. The compounds according to the invention are glycogen phosphorylase inhibitors and can be used e.g. for the treatment of type 2 diabetes, cardiovascular disorders and tumorous growth.˙
Inventors:
SOMSAK LASZLO (HU)
BOKOR EVA (HU)
VAGVOELGYINE TOTH MARIETTA (HU)
JUHASZ LASZLO (HU)
CZIFRAK KATALIN (HU)
KONYA BALINT (HU)
KUN SANDOR (HU)
PAHI ANDRAS (HU)
SZOCS BELA (HU)
VARGA GERGELY (HU)
GERGELY PAL (HU)
DOCSA TIBOR (HU)
KODER LASZLONE (HU)
NAGY KAROLYNE (HU)
BOKOR EVA (HU)
VAGVOELGYINE TOTH MARIETTA (HU)
JUHASZ LASZLO (HU)
CZIFRAK KATALIN (HU)
KONYA BALINT (HU)
KUN SANDOR (HU)
PAHI ANDRAS (HU)
SZOCS BELA (HU)
VARGA GERGELY (HU)
GERGELY PAL (HU)
DOCSA TIBOR (HU)
KODER LASZLONE (HU)
NAGY KAROLYNE (HU)
Application Number:
PCT/HU2012/000116
Publication Date:
September 19, 2013
Filing Date:
October 27, 2012
Export Citation:
Assignee:
DEBRECENI EGYETEM (HU)
International Classes:
C07H19/052; A61K31/7042; A61P9/06; A61P9/08; A61P9/10; C07H19/056
Attorney, Agent or Firm:
DANUBIA PATENT & LAW OFFICE LLC (Bajcsy Zs. út 16, Budapest, HU)
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