Title:
GLYCOLIPID DERIVATIVE AND THERAPEUTIC AGENT COMPRISING THE SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2007/004705
Kind Code:
A1
Abstract:
A glycolipid derivative represented by the formula (I): (I) wherein R1 represents
an aldopyranaose residue, R2 represents a hydrogen atom or a hydroxyl
group, A represents -CH2-,-CH(OH)-CH2- or -CH=CHCH2-,
Z represents -O- or -CH2-, and y represents an integer of 26 to 35 when
Z represents -O- and x represents an integer of 4 to 16, y represents an integer
of 0 to 35 when Z represents -O- and x represents an integer of 17 to 25, y represents
an integer of 26 to 35 when Z represents -CH2- and x represents an integer
of 4 to 15 and y represents an integer of 0 to 35 when Z represents -CH2-
and x represents an integer of 16 to 25; and a therapeutic agent for an autoimmune
disease (e.g., autoimmune arthritis), an allergic disease (e.g., bronchial
asthma) or a disease of which an NKT cell or the stimulation of an NKT cell is known
to be involved in the aggravation of the condition comprising the glycolipid
derivative.
Inventors:
MIYAKE SACHIKO (JP)
YAMAMURA TAKASHI (JP)
TOBA TETSUYA (JP)
YAMAMURA TAKASHI (JP)
TOBA TETSUYA (JP)
Application Number:
PCT/JP2006/313519
Publication Date:
January 11, 2007
Filing Date:
June 30, 2006
Export Citation:
Assignee:
JAPAN GOVERNMENT (JP)
DAIICHI ASUBIO PHARMA CO LTD (JP)
MIYAKE SACHIKO (JP)
YAMAMURA TAKASHI (JP)
TOBA TETSUYA (JP)
DAIICHI ASUBIO PHARMA CO LTD (JP)
MIYAKE SACHIKO (JP)
YAMAMURA TAKASHI (JP)
TOBA TETSUYA (JP)
International Classes:
C07D309/10; A61K31/351; A61K31/7032; A61P37/02; A61P37/08; C07H15/04
Domestic Patent References:
| WO2004072091A1 | 2004-08-26 | |||
| WO1998044928A1 | 1998-10-15 | |||
| WO2003105769A2 | 2003-12-24 | |||
| WO2003016326A1 | 2003-02-27 | |||
| WO1994002168A1 | 1994-02-03 |
Foreign References:
| JP2004217601A | 2004-08-05 |
Attorney, Agent or Firm:
AOKI, Atsushi et al. (Toranomon 37 Mori Bldg. 5-1, Toranomon 3-chom, Minato-ku Tokyo, JP)
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