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Title:
GLYCOLIPID DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, INTERMEDIATES FOR SYNTHESIS THEREOF, AND PROCESS FOR PRODUCTION OF THE INTERMEDIATES
Document Type and Number:
WIPO Patent Application WO/2004/072091
Kind Code:
A1
Abstract:
Novel glycolipid derivatives wherein the substituent of the sphingosine base moiety is alkyl having a shorter carbon chain, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl; an efficient process for mass-producing the same economically; and intermediates useful in the production thereof. Specifically, glycolipid derivatives represented by the general formula (I) are chemically synthesized: (I) wherein R3 is substituted or unsubstituted linear alkyl having 1 to 7 carbon atoms, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl; and R8 is substituted or unsubstituted alkyl having 1 to 35 carbon atoms, substituted or unsubstituted aryl, or substituted or unsubstituted aralkyl.

Inventors:
Annoura, Hirokazu (10-17, Kitabatake Chouhouj, Nagaokakyo-shi Kyoto 12, 61708, JP)
Murata, Kenji (2-7-21, Mitsukeyama Ibaraki-shi, Osaka 35, 56700, JP)
Yamamura, Takashi (1-6-44, Hikaricho Kokubunji-shi, Tokyo 34, 18500, JP)
Application Number:
PCT/JP2004/001566
Publication Date:
August 26, 2004
Filing Date:
February 13, 2004
Export Citation:
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Assignee:
DAIICHI SUNTORY PHARMA CO., LTD. (7-2 Kojimachi 5-chome, Chiyoda-ku, Tokyo 30, 10285, JP)
JAPAN as represented by PRESIDENT OF NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY (4-1-1, Ogawahigashicho Kodaira-shi, Tokyo 02, 18785, JP)
Annoura, Hirokazu (10-17, Kitabatake Chouhouj, Nagaokakyo-shi Kyoto 12, 61708, JP)
Murata, Kenji (2-7-21, Mitsukeyama Ibaraki-shi, Osaka 35, 56700, JP)
Yamamura, Takashi (1-6-44, Hikaricho Kokubunji-shi, Tokyo 34, 18500, JP)
International Classes:
A61P37/02; C07C247/04; C07D317/28; C07H15/04; C07H15/26; (IPC1-7): C07H15/04; A61K31/7032; A61P37/02; C07C247/04; C07C247/10; C07D317/28; C07H15/26
Attorney, Agent or Firm:
Aoki, Atsushi (A. Aoki, Ishida & Associates Toranomon 37 Mori Bldg., 5-1, Toranomon 3-chom, Minato-ku Tokyo 23, 10584, JP)
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