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Title:
GLYCOSIDE DERIVATIVE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/048148
Kind Code:
A3
Abstract:
This invention relates to compounds represented by formula (I) wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.

Inventors:
BEBERNITZ, Gregory Raymond (Novartis Institutes for BioMedical Research, Inc.100 Technology Squar, Cambridge Massachusetts, 02139, US)
BOCK, Mark G. (Novartis Institutes for BioMedical Research, Inc.250 Massachusetts Avenu, Cambridge Massachusetts, 02139, US)
BHUNIYA, Debnath (Post Khalisani, Howrah, West Bengal 7, 711 03, IN)
DATRANGE, Laxmikant (Advinus Therapeutics Limited, of 21 and 22 Phase II,Peenya Industrial Area, Bangalore 8, 56005, IN)
KURHADE, Suresh Eknath (Lawanwadi, Post AleTal. Junna, Pune Maharashtra 1, 412 41, IN)
PALLE, P. Venkata (24 Gera Green Ville, Survey No. 64 Kharad, Pune Maharashtra 4, 411 01, IN)
REDDY, Dumbala Srinivas (Alpha 605, Jayabheri Silicon CountyHi-Tec City Road, Kondapu, Hyderabad Andhra Pradesh 2, 500 03, IN)
Application Number:
EP2010/065802
Publication Date:
June 30, 2011
Filing Date:
October 20, 2010
Export Citation:
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Assignee:
NOVARTIS AG (Lichtstrasse 35, Basel, CH-4056, CH)
BEBERNITZ, Gregory Raymond (Novartis Institutes for BioMedical Research, Inc.100 Technology Squar, Cambridge Massachusetts, 02139, US)
BOCK, Mark G. (Novartis Institutes for BioMedical Research, Inc.250 Massachusetts Avenu, Cambridge Massachusetts, 02139, US)
BHUNIYA, Debnath (Post Khalisani, Howrah, West Bengal 7, 711 03, IN)
DATRANGE, Laxmikant (Advinus Therapeutics Limited, of 21 and 22 Phase II,Peenya Industrial Area, Bangalore 8, 56005, IN)
KURHADE, Suresh Eknath (Lawanwadi, Post AleTal. Junna, Pune Maharashtra 1, 412 41, IN)
PALLE, P. Venkata (24 Gera Green Ville, Survey No. 64 Kharad, Pune Maharashtra 4, 411 01, IN)
REDDY, Dumbala Srinivas (Alpha 605, Jayabheri Silicon CountyHi-Tec City Road, Kondapu, Hyderabad Andhra Pradesh 2, 500 03, IN)
International Classes:
C07H15/203; A61K31/351; A61K31/7034; A61K31/7042; A61K31/7056; A61P3/10; C07D309/10; C07D309/30; C07D405/10; C07D407/10; C07D407/12; C07D409/04; C07D409/10; C07D409/12; C07D413/10; C07D491/107; C07D493/10; C07D498/04; C07H15/26; C07H17/00; C07H19/04
Domestic Patent References:
WO2001027128A12001-04-19
WO2008013322A12008-01-31
Foreign References:
EP2048150A12009-04-15
EP1609785A12005-12-28
Other References:
ROBINSON R P ET AL: "C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 20, no. 5, 1 March 2010 (2010-03-01), pages 1569 - 1572, XP026911306, ISSN: 0960-894X, [retrieved on 20100217], DOI: DOI:10.1016/J.BMCL.2010.01.075
MASCITTI V ET AL: "Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 51, no. 14, 7 April 2010 (2010-04-07), pages 1880 - 1883, XP026934860, ISSN: 0040-4039, [retrieved on 20100210], DOI: DOI:10.1016/J.TETLET.2010.02.024
HUBER R. ET AL: "Synthesis of Potential Glucosidase-Inhibitors: D-Xylopyranoside-5-spiro-l'-cyclopropanes", HELVETICA CHIMICA ACTA, vol. 73, no. 5, 8 August 1990 (1990-08-08), pages 1329 - 1337, XP002618916, DOI: 10.1002/hlca.19900730521
Attorney, Agent or Firm:
CAMPBELL, Lachlan (Novartis Pharma Ag, Patent Department, Basel, CH-4002, CH)
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