Title:
GLYCOSYLATED CHLORIN E6 DERIVATIVE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PHARMACEUTICAL COMPOSITION, METHOD FOR DESTROYING TARGET, AND METHOD FOR PRODUCING GLYCOSYLATED CHLORIN E6 DERIVATIVE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/101434
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a glycosylated chlorin e6 derivative which has excellent tumor cell-killing properties (phototoxic property) and growth-inhibiting effect on tumor tissues and which is used for photodynamic therapy. The glycosylated chlorin e6 derivative according to the present invention is applicable for use in photodynamic diagnosis as well. The present invention pertains to a glycosylated chlorin e6 derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof.
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Inventors:
YANO SHIGENOBU (JP)
KATAOKA HIROMI (JP)
NISHIE HIROTADA (JP)
JOH TAKASHI (JP)
FUKUMOTO KEISUKE (JP)
NAKANO YASUHIRO (JP)
KATAOKA HIROMI (JP)
NISHIE HIROTADA (JP)
JOH TAKASHI (JP)
FUKUMOTO KEISUKE (JP)
NAKANO YASUHIRO (JP)
Application Number:
PCT/JP2017/043144
Publication Date:
June 07, 2018
Filing Date:
November 30, 2017
Export Citation:
Assignee:
UNIV NAGOYA CITY PUBLIC UNIV CORP (JP)
YANO SHIGENOBU (JP)
FUJIFILM CORP (JP)
YANO SHIGENOBU (JP)
FUJIFILM CORP (JP)
International Classes:
C07H15/14; A61K31/7052; A61P17/00; A61P27/02; A61P35/00; A61P43/00
Domestic Patent References:
| WO2008102669A1 | 2008-08-28 |
Foreign References:
| JP2004532890A | 2004-10-28 | |||
| CN1113914A | 1995-12-27 |
Other References:
LONIN, I. S. ET AL.: "Synthesis of chlorophyll a glycoconjugates using olefin cross-metathesis", MENDELEEV COMMUNICATIONS, vol. 22, no. 3, 2012, pages 157 - 8, XP028512084, DOI: doi:10.1016/j.mencom.2012.05.016
AKSENOVA, A. A. ET AL.: "The synthesis of galactopyranosyl-substituted derivatives of pheophorbide", RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol. 26, no. 2, 2000, pages 111 - 114, XP055605928, ISSN: 1068-1620
SYLVAIN, I. ET AL.: "Synthesis and biological evaluation of thioglycosylated porphyrins for an application in photodynamic therapy", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 1, 2002, pages 57 - 69, XP055605932
AKSENOVA, A. A. ET AL.: "Synthesis and properties of 0- and S-glycosylated derivatives of pyropheophorbide a", RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol. 27, no. 2, 2001, pages 124 - 9, ISSN: 1068-1620
JIANG, X. ET AL.: "Synthesis of nucleoside adducts of porphyrins and chlorophyll derivatives", TETRAHEDRON LETTERS, vol. 36, no. 3, 1995, pages 365 - 8, XP004028824, DOI: doi:10.1016/0040-4039(94)02271-C
FUHRHOP, J. H. ET AL.: "Chiral micellar porphyrin fibers with 2-aminoglycosamide head groups", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, no. 11, 1992, pages 4159 - 4165, XP055605939
CIECKIEWICZ, E. ET AL.: "Semisynthesis and in vitro photodynamic activity evaluations of halogenated and glycosylated derivatives of pheophorbide a", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. 27, 2015, pages 6061 - 74, XP055605942
YANO SHIGENOBU ET AL.: "Development of next generation light-sensitive sugar chain-linked photo sensitizing substance through medical engineering collaborations", MEDICAL PHOTONICS, vol. 2, no. 22, 13 July 2016 (2016-07-13), pages 19 - 28
AKSENOVA, A. A. ET AL.: "The synthesis of galactopyranosyl-substituted derivatives of pheophorbide", RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol. 26, no. 2, 2000, pages 111 - 114, XP055605928, ISSN: 1068-1620
SYLVAIN, I. ET AL.: "Synthesis and biological evaluation of thioglycosylated porphyrins for an application in photodynamic therapy", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 10, no. 1, 2002, pages 57 - 69, XP055605932
AKSENOVA, A. A. ET AL.: "Synthesis and properties of 0- and S-glycosylated derivatives of pyropheophorbide a", RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, vol. 27, no. 2, 2001, pages 124 - 9, ISSN: 1068-1620
JIANG, X. ET AL.: "Synthesis of nucleoside adducts of porphyrins and chlorophyll derivatives", TETRAHEDRON LETTERS, vol. 36, no. 3, 1995, pages 365 - 8, XP004028824, DOI: doi:10.1016/0040-4039(94)02271-C
FUHRHOP, J. H. ET AL.: "Chiral micellar porphyrin fibers with 2-aminoglycosamide head groups", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 114, no. 11, 1992, pages 4159 - 4165, XP055605939
CIECKIEWICZ, E. ET AL.: "Semisynthesis and in vitro photodynamic activity evaluations of halogenated and glycosylated derivatives of pheophorbide a", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. 27, 2015, pages 6061 - 74, XP055605942
YANO SHIGENOBU ET AL.: "Development of next generation light-sensitive sugar chain-linked photo sensitizing substance through medical engineering collaborations", MEDICAL PHOTONICS, vol. 2, no. 22, 13 July 2016 (2016-07-13), pages 19 - 28
Attorney, Agent or Firm:
WATANABE Mochitoshi et al. (JP)
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