Title:
GLYCOSYLATION INHIBITORS AS THERAPEUTICS FOR STROKE
Document Type and Number:
WIPO Patent Application WO/2023/205124
Kind Code:
A3
Abstract:
Pharmaceutical compositions for treating an ischemic condition in a subject may include inhibitors of protein glycosylation. Methods may include administering to the subject in need thereof an effective amount an inhibitor of protein glycosylation. The administration may be effective to promote endothelial cell proliferation and angiogenesis in the subject. The subject may be in need of induced angiogenesis due to an ischemic condition caused by a stroke. Pharmaceutical compositions for inhibiting protein glycosylation in a cell may include ManN. Methods for inhibiting protein glycosylation in a cell may include administering to a cell an effective amount of ManN.
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Inventors:
FERRARA NAPOLEONE (US)
LI PIN (US)
LI PIN (US)
Application Number:
PCT/US2023/018909
Publication Date:
November 23, 2023
Filing Date:
April 18, 2023
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
International Classes:
A61P9/10; A61K31/7008; A61K45/06; A61P9/00
Domestic Patent References:
| WO2022087107A1 | 2022-04-28 |
Foreign References:
| US20200046747A1 | 2020-02-13 | |||
| US20210115082A1 | 2021-04-22 | |||
| US10119979B2 | 2018-11-06 |
Other References:
ANONYMOUS: "The Warning Signs of Stroke", WEBMD, 20 September 2023 (2023-09-20), XP093115320, Retrieved from the Internet [retrieved on 20240102]
SCOTT DAVID W., CHEN JIE, CHACKO BALU K., TRAYLOR JAMES G., ORR ANTHONY W., PATEL RAKESH P.: "Role of Endothelial N-Glycan Mannose Residues in Monocyte Recruitment During Atherogenesis", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 32, no. 8, 1 August 2012 (2012-08-01), XP093115322, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.112.253203
CORAZZARI MARCO, GAGLIARDI MARA, FIMIA GIAN MARIA, PIACENTINI MAURO: "Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate", FRONTIERS IN ONCOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 7, CH , XP093115324, ISSN: 2234-943X, DOI: 10.3389/fonc.2017.00078
ZHONG CUILING, LI PIN, ARGADE SULABHA, LIU LIXIAN, CHILLA’ ANASTASIA, LIANG WEI, XIN HONG, ELICEIRI BRIAN, CHOUDHURY BISWA, FERRAR: "Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 11, no. 1, UK, XP093115326, ISSN: 2041-1723, DOI: 10.1038/s41467-020-20108-0
SCOTT DAVID W., CHEN JIE, CHACKO BALU K., TRAYLOR JAMES G., ORR ANTHONY W., PATEL RAKESH P.: "Role of Endothelial N-Glycan Mannose Residues in Monocyte Recruitment During Atherogenesis", TRANSLATIONAL SCIENCES, LIPPINCOTT, WILLIAMS & WILKINS, vol. 32, no. 8, 1 August 2012 (2012-08-01), XP093115322, ISSN: 1079-5642, DOI: 10.1161/ATVBAHA.112.253203
CORAZZARI MARCO, GAGLIARDI MARA, FIMIA GIAN MARIA, PIACENTINI MAURO: "Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate", FRONTIERS IN ONCOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 7, CH , XP093115324, ISSN: 2234-943X, DOI: 10.3389/fonc.2017.00078
ZHONG CUILING, LI PIN, ARGADE SULABHA, LIU LIXIAN, CHILLA’ ANASTASIA, LIANG WEI, XIN HONG, ELICEIRI BRIAN, CHOUDHURY BISWA, FERRAR: "Inhibition of protein glycosylation is a novel pro-angiogenic strategy that acts via activation of stress pathways", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, UK, vol. 11, no. 1, UK, XP093115326, ISSN: 2041-1723, DOI: 10.1038/s41467-020-20108-0
Attorney, Agent or Firm:
WARREN, William L. et al. (US)
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