Title:
GLYOXALASE I IRREVERSIBLE INHIBITOR, PREPARATION METHOD THEREFOR, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/158306
Kind Code:
A1
Abstract:
Provided are a glyoxalase I irreversible inhibitor as represented by the formula I, a preparation method therefor, and uses thereof. In the present invention, an irreversible inhibitor reacts with glyoxalase I in a covalent bond mode so that the glyoxalase I losses the activity irreversibly. The glyoxalase I irreversible inhibitor has good development and application prospects in the aspects of medicaments for treating malignant tumors such as prostate cancer, lung cancer, intestinal cancer, bladder cancer, leukemia, mammary cancer, and skin cancer as well as various recurrent tumors.
Inventors:
ZHENG ZHEBIN (CN)
Application Number:
PCT/CN2015/076899
Publication Date:
October 22, 2015
Filing Date:
April 17, 2015
Export Citation:
Assignee:
UNIV CHENGDU (CN)
International Classes:
C07K5/037; A61K31/4745; A61K38/06; A61P19/10; A61P35/00; A61P35/02; A61P35/04; C07D513/04
Foreign References:
| CN103183722A | 2013-07-03 |
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERALPARTNERSHIP) (CN)
成都高远知识产权代理事务所(普通合伙) (CN)
成都高远知识产权代理事务所(普通合伙) (CN)
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